eF-site ID 2q5s-A PDB Code 2q5s Chain A click to enlarge Title Crystal Structure of PPARgamma bound to partial agonist nTZDpa Classification Ligand binding protein Compound Peroxisome Proliferator-Activated Receptor gamma Source Homo sapiens (Human) (PPARG_HUMAN) Sequence A:  SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPF VIYDMNSLMMGEDKEVAIRIFQGCQFRSVEAVQEITEYAK SIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLI SEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDD SDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQL KLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTET DMSLHPLLQEIYKDLY Description Functional site 1) chain A residue 281 type sequence I description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 2) chain A residue 284 type sequence G description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 3) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 4) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 5) chain A residue 292 type sequence A description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 6) chain A residue 326 type sequence I description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 7) chain A residue 333 type sequence L description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 8) chain A residue 340 type sequence L description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 9) chain A residue 341 type sequence I description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 10) chain A residue 342 type sequence S description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 11) chain A residue 348 type sequence M description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 12) chain A residue 353 type sequence L description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 13) chain A residue 363 type sequence F description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 14) chain A residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 15) chain A residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 16) chain A residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 17) chain A residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 18) chain A residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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