|
eF-site ID
|
2q5d-ABCD |
PDB Code
|
2q5d |
Chain
|
A, B, C, D |
|
click to enlarge
|
|
Title
|
Crystal Structure of Human Importin Beta bound to the Snurportin1 IBB-domain second crystal form |
Classification
|
PROTEIN TRANSPORT |
Compound
|
Importin beta-1 subunit |
Source
|
Homo sapiens (Human) (SPN1_HUMAN) |
|
Sequence
|
A: |
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVEL
SRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRW
LAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD
IDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLN
SLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGI
EFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQ
YLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPS
QLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP
EAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA
AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGH
QNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQ
VLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA
LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLG
GEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRA
LQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI
ALAIGGEFKKYLEVVLNTLQQASQAQVDMVDYLNELRESC
LEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIA
GDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHE
LLTEGRRSKTNKAKTLATWATKELRKLKNQA
|
B: |
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVEL
SRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRW
LAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD
IDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLN
SLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGI
EFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQ
YLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPS
QLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP
EAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA
AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGH
QNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQ
VLQMSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVV
MASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYM
EAFKPFLGIGQVCLAAVGLVGDLCRALQSNIIPFCDEVMQ
LLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEV
VLNTLQQASQAQVYLNELRESCLEAYTGIVQGQPDVMLVQ
PRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGK
DVLKLVEARPMIHELLTEGRRSKTNKAKTLATWATKELRK
LKNQA
|
C: |
PRLSQYKSKYEQSERRRRLLELQKSKRLDYVNHARR
|
D: |
ERRRRLLELQKSKRLDYVNHARR
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
1 |
type |
MOD_RES |
sequence |
M
|
description |
N-acetylmethionine => ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
2)
|
chain |
B |
residue |
1 |
type |
MOD_RES |
sequence |
M
|
description |
N-acetylmethionine => ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
A |
residue |
12 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
B |
residue |
12 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
5)
|
chain |
A |
residue |
211 |
type |
MOD_RES |
sequence |
K
|
description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
6)
|
chain |
A |
residue |
835 |
type |
MOD_RES |
sequence |
K
|
description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
7)
|
chain |
A |
residue |
867 |
type |
MOD_RES |
sequence |
K
|
description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
8)
|
chain |
B |
residue |
211 |
type |
MOD_RES |
sequence |
K
|
description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
9)
|
chain |
B |
residue |
835 |
type |
MOD_RES |
sequence |
K
|
description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
10)
|
chain |
B |
residue |
867 |
type |
MOD_RES |
sequence |
K
|
description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|