eF-site ID 2q0c-A PDB Code 2q0c Chain A click to enlarge Title Terminal uridylyl transferase 4 from Trypanosoma brucei with bound CTP Classification TRANSFERASE Compound RNA uridylyl transferase Source Trypanosoma brucei brucei (strain 927/4 GUTat10.1) (Q381M1_9TRYP) Sequence A:  PSPAVVGRSLVNSFKQFVSKRHVDATYRLVLDCVAAVDPL MRLYTFGSTVVYGVHEKGSDVDFVVLNKTDVEDGKGGDAA TQVAKGLQADILAKLARVIRQKHLSWNVEEVRRTRVPVVR VKGGGAVDFDITAYRRNGVRNSALLRAYFEQNPPCRWLSM SIKRWSKQTGLNASVIGGSITSYGFNLMVVYYLLQRNHLQ FVPPSTIDVSRVEPLPPHLPLEEPADEGLELGTQVLDFLH FFLHEFDSDKQVISLNRPGITTKEELDWTKSAEDFARMNG EKVHYQWCIEDPYELNLNVGRNVTPLKRDFLRRHLEKARD TALLTIV Description Functional site 1) chain A residue 66 type sequence D description BINDING SITE FOR RESIDUE MG A 401 source : AC1 2) chain A residue 68 type sequence D description BINDING SITE FOR RESIDUE MG A 401 source : AC1 3) chain A residue 52 type sequence F description BINDING SITE FOR RESIDUE CTP A 501 source : AC2 4) chain A residue 53 type sequence G description BINDING SITE FOR RESIDUE CTP A 501 source : AC2 5) chain A residue 54 type sequence S description BINDING SITE FOR RESIDUE CTP A 501 source : AC2 6) chain A residue 65 type sequence S description BINDING SITE FOR RESIDUE CTP A 501 source : AC2 7) chain A residue 66 type sequence D description BINDING SITE FOR RESIDUE CTP A 501 source : AC2 8) chain A residue 68 type sequence D description BINDING SITE FOR RESIDUE CTP A 501 source : AC2 9) chain A residue 144 type sequence G description BINDING SITE FOR RESIDUE CTP A 501 source : AC2 10) chain A residue 147 type sequence N description BINDING SITE FOR RESIDUE CTP A 501 source : AC2 11) chain A residue 148 type sequence S description BINDING SITE FOR RESIDUE CTP A 501 source : AC2 12) chain A residue 169 type sequence K description BINDING SITE FOR RESIDUE CTP A 501 source : AC2 13) chain A residue 173 type sequence K description BINDING SITE FOR RESIDUE CTP A 501 source : AC2 14) chain A residue 188 type sequence S description BINDING SITE FOR RESIDUE CTP A 501 source : AC2 15) chain A residue 189 type sequence Y description BINDING SITE FOR RESIDUE CTP A 501 source : AC2 16) chain A residue 54 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 17) chain A residue 65 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 18) chain A residue 144 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 19) chain A residue 169 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 20) chain A residue 173 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 21) chain A residue 188 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI1 22) chain A residue 121 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:2Q0G, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI3 23) chain A residue 136 type SITE sequence D description Important for catalytic activity => ECO:0000269|PubMed:17189640 source Swiss-Prot : SWS_FT_FI4 24) chain A residue 66 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2NOM, ECO:0007744|PDB:2Q0C, ECO:0007744|PDB:2Q0D, ECO:0007744|PDB:2Q0E, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:2Q0G, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI2 25) chain A residue 68 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17189640, ECO:0000269|PubMed:17785418, ECO:0000269|PubMed:27744351, ECO:0007744|PDB:2IKF, ECO:0007744|PDB:2NOM, ECO:0007744|PDB:2Q0C, ECO:0007744|PDB:2Q0D, ECO:0007744|PDB:2Q0E, ECO:0007744|PDB:2Q0F, ECO:0007744|PDB:2Q0G, ECO:0007744|PDB:5KAL source Swiss-Prot : SWS_FT_FI2

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