|
eF-site ID
|
2pzy-D |
PDB Code
|
2pzy |
Chain
|
D |
|
click to enlarge
|
|
Title
|
Structure of MK2 Complexed with Compound 76 |
Classification
|
TRANSFERASE |
Compound
|
MAP kinase-activated protein kinase 2 |
Source
|
Homo sapiens (Human) (MAPK2_HUMAN) |
|
Sequence
|
D: |
FPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIF
NKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVD
VYENLYAGRKCLLIVMECLDGGELFSRIQDRFTEREASEI
MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLT
DFGFAKETTCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMY
ILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV
SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT
PLHTSRVL
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
D |
residue |
186 |
type |
ACT_SITE |
sequence |
D
|
description |
Proton acceptor
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
2)
|
chain |
D |
residue |
70 |
type |
BINDING |
sequence |
L
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
3)
|
chain |
D |
residue |
93 |
type |
BINDING |
sequence |
K
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
D |
residue |
139 |
type |
BINDING |
sequence |
E
|
description |
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
5)
|
chain |
D |
residue |
272 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine; by MAPK14 => ECO:0000269|PubMed:8846784
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
6)
|
chain |
D |
residue |
328 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine; by autocatalysis => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
7)
|
chain |
D |
residue |
334 |
type |
MOD_RES |
sequence |
T
|
description |
Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
|
source |
Swiss-Prot : SWS_FT_FI7
|
|
|
|