|
|
eF-site ID
|
2pzy-B |
|
PDB Code
|
2pzy |
|
Chain
|
B |
|
click to enlarge
|
|
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Title
|
Structure of MK2 Complexed with Compound 76 |
|
Classification
|
TRANSFERASE |
|
Compound
|
MAP kinase-activated protein kinase 2 |
|
Source
|
Homo sapiens (Human) (MAPK2_HUMAN) |
|
|
Sequence
|
B: |
PQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFN
KRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDV
YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREA
SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAIL
KLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMY
ILLCGYPPFYSGMKTRIRMGQYEFPNPEWSEVSEEVKMLI
RNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL
KED
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
334 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
2)
|
chain |
B |
| residue |
328 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by autocatalysis => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
3)
|
chain |
B |
| residue |
186 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
70 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
B |
| residue |
93 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
B |
| residue |
139 |
| type |
BINDING |
| sequence |
E
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|