eF-site ID 2pzr-AB PDB Code 2pzr Chain A, B click to enlarge Title Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K641R Mutation Responsible for Pfeiffer Syndrome Classification TRANSFERASE Compound Fibroblast growth factor receptor 2 Source Homo sapiens (Human) (FGFR2_HUMAN) Sequence A:  LPEDPKWEFPRDKLTLGKPLQVVMAEAVGIDKDKPKEAVT VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGA CTQDGPLYVIVEYASKGNLREYLRARRPPEEQMTFKDLVS CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMRIADF GLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD VWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT B:  ELPEDPKWEFPRDKLTLGKPLQVVMAEAVGIDKDKPKEAV TVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLG ACTQDGPLYVIVEYASKGNLREYLRARRPPEEQMTFKDLV SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMRIAD FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT TN Description Functional site 1) chain A residue 625 type sequence R description BINDING SITE FOR RESIDUE SO4 A 801 source : AC1 2) chain A residue 647 type sequence L description BINDING SITE FOR RESIDUE SO4 A 801 source : AC1 3) chain A residue 649 type sequence R description BINDING SITE FOR RESIDUE SO4 A 801 source : AC1 4) chain A residue 664 type sequence R description BINDING SITE FOR RESIDUE SO4 A 801 source : AC1 5) chain A residue 737 type sequence R description BINDING SITE FOR RESIDUE SO4 A 802 source : AC2 6) chain B residue 743 type sequence V description BINDING SITE FOR RESIDUE SO4 A 802 source : AC2 7) chain B residue 744 type sequence P description BINDING SITE FOR RESIDUE SO4 A 802 source : AC2 8) chain B residue 745 type sequence S description BINDING SITE FOR RESIDUE SO4 A 802 source : AC2 9) chain A residue 495 type sequence V description BINDING SITE FOR RESIDUE ACP A 803 source : AC3 10) chain A residue 515 type sequence A description BINDING SITE FOR RESIDUE ACP A 803 source : AC3 11) chain A residue 565 type sequence E description BINDING SITE FOR RESIDUE ACP A 803 source : AC3 12) chain A residue 567 type sequence A description BINDING SITE FOR RESIDUE ACP A 803 source : AC3 13) chain A residue 633 type sequence L description BINDING SITE FOR RESIDUE ACP A 803 source : AC3 14) chain B residue 625 type sequence R description BINDING SITE FOR RESIDUE SO4 B 801 source : AC4 15) chain B residue 649 type sequence R description BINDING SITE FOR RESIDUE SO4 B 801 source : AC4 16) chain B residue 664 type sequence R description BINDING SITE FOR RESIDUE SO4 B 801 source : AC4 17) chain B residue 729 type sequence T description BINDING SITE FOR RESIDUE SO4 B 802 source : AC5 18) chain B residue 730 type sequence N description BINDING SITE FOR RESIDUE SO4 B 802 source : AC5 19) chain B residue 487 type sequence L description BINDING SITE FOR RESIDUE ACP B 803 source : AC6 20) chain B residue 515 type sequence A description BINDING SITE FOR RESIDUE ACP B 803 source : AC6 21) chain B residue 565 type sequence E description BINDING SITE FOR RESIDUE ACP B 803 source : AC6 22) chain B residue 566 type sequence Y description BINDING SITE FOR RESIDUE ACP B 803 source : AC6 23) chain B residue 567 type sequence A description BINDING SITE FOR RESIDUE ACP B 803 source : AC6 24) chain B residue 633 type sequence L description BINDING SITE FOR RESIDUE ACP B 803 source : AC6 25) chain A residue 626 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 626 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 487 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 517 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 565 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 571 type BINDING sequence N description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 31) chain B residue 487 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 32) chain B residue 517 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 565 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 571 type BINDING sequence N description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 656 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646 source Swiss-Prot : SWS_FT_FI4 36) chain A residue 657 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646 source Swiss-Prot : SWS_FT_FI4 37) chain B residue 656 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646 source Swiss-Prot : SWS_FT_FI4 38) chain B residue 657 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646 source Swiss-Prot : SWS_FT_FI4 39) chain A residue 487-517 type prosite sequence LQVVMAEAVGIDKDKPKEAVTVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVmAeavgidkdkpkeavt...VAVK source prosite : PS00107 40) chain A residue 622-634 type prosite sequence CIHRDLAARNVLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV source prosite : PS00109

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