eF-site ID 2pzp-A PDB Code 2pzp Chain A click to enlarge Title Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible for Crouzon Syndrome Classification TRANSFERASE Compound Fibroblast growth factor receptor 2 Source Homo sapiens (Human) (FGFR2_HUMAN) Sequence A:  LPEDPKWEFPRDKLTLGKPLQVVMAEAVGIDKDKPKEAVT VAVKMLKDDATEEDLSDLVSEMEMMKMIGKHKNIINLLGA CTQDGPLYVIVEYASKGNLREYLRARRPEEQMTFKDLVSC TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN Description Functional site 1) chain A residue 625 type sequence R description BINDING SITE FOR RESIDUE SO4 A 303 source : AC1 2) chain A residue 649 type sequence R description BINDING SITE FOR RESIDUE SO4 A 303 source : AC1 3) chain A residue 664 type sequence R description BINDING SITE FOR RESIDUE SO4 A 303 source : AC1 4) chain A residue 737 type sequence R description BINDING SITE FOR RESIDUE SO4 A 304 source : AC2 5) chain A residue 631 type sequence N description BINDING SITE FOR RESIDUE MG A 301 source : AC5 6) chain A residue 644 type sequence D description BINDING SITE FOR RESIDUE MG A 301 source : AC5 7) chain A residue 644 type sequence D description BINDING SITE FOR RESIDUE MG A 302 source : AC6 8) chain A residue 515 type sequence A description BINDING SITE FOR RESIDUE ACP A 300 source : AC9 9) chain A residue 517 type sequence K description BINDING SITE FOR RESIDUE ACP A 300 source : AC9 10) chain A residue 564 type sequence V description BINDING SITE FOR RESIDUE ACP A 300 source : AC9 11) chain A residue 565 type sequence E description BINDING SITE FOR RESIDUE ACP A 300 source : AC9 12) chain A residue 567 type sequence A description BINDING SITE FOR RESIDUE ACP A 300 source : AC9 13) chain A residue 571 type sequence N description BINDING SITE FOR RESIDUE ACP A 300 source : AC9 14) chain A residue 630 type sequence R description BINDING SITE FOR RESIDUE ACP A 300 source : AC9 15) chain A residue 631 type sequence N description BINDING SITE FOR RESIDUE ACP A 300 source : AC9 16) chain A residue 633 type sequence L description BINDING SITE FOR RESIDUE ACP A 300 source : AC9 17) chain A residue 644 type sequence D description BINDING SITE FOR RESIDUE ACP A 300 source : AC9 18) chain A residue 487-517 type prosite sequence LQVVMAEAVGIDKDKPKEAVTVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVmAeavgidkdkpkeavt...VAVK source prosite : PS00107 19) chain A residue 622-634 type prosite sequence CIHRDLAARNVLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV source prosite : PS00109 20) chain A residue 626 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 565 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 571 type BINDING sequence N description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 487 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 517 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 656 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646 source Swiss-Prot : SWS_FT_FI4 26) chain A residue 657 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646 source Swiss-Prot : SWS_FT_FI4

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