eF-site ID 2pze-A PDB Code 2pze Chain A click to enlarge Title Minimal human CFTR first nucleotide binding domain as a head-to-tail dimer Classification HYDROLASE Compound Cystic fibrosis transmembrane conductance regulator Source (CFTR_HUMAN) Sequence A:  SLTTTEVVMENVTAFWEEGGTPVLKDINFKIERGQLLAVA GSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWI MPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKD NIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGY LDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKIL ILHEGSSYFYGTFSELQNLDFSSKLM Description Functional site 1) chain A residue 465 type sequence T description BINDING SITE FOR RESIDUE MG A 3 source : AC1 2) chain A residue 493 type sequence Q description BINDING SITE FOR RESIDUE MG A 3 source : AC1 3) chain A residue 401 type sequence W description BINDING SITE FOR RESIDUE ATP A 1 source : AC3 4) chain A residue 440 type sequence V description BINDING SITE FOR RESIDUE ATP A 1 source : AC3 5) chain A residue 460 type sequence T description BINDING SITE FOR RESIDUE ATP A 1 source : AC3 6) chain A residue 461 type sequence G description BINDING SITE FOR RESIDUE ATP A 1 source : AC3 7) chain A residue 462 type sequence A description BINDING SITE FOR RESIDUE ATP A 1 source : AC3 8) chain A residue 463 type sequence G description BINDING SITE FOR RESIDUE ATP A 1 source : AC3 9) chain A residue 464 type sequence K description BINDING SITE FOR RESIDUE ATP A 1 source : AC3 10) chain A residue 465 type sequence T description BINDING SITE FOR RESIDUE ATP A 1 source : AC3 11) chain A residue 466 type sequence S description BINDING SITE FOR RESIDUE ATP A 1 source : AC3 12) chain A residue 493 type sequence Q description BINDING SITE FOR RESIDUE ATP A 1 source : AC3 13) chain A residue 547 type sequence T description BINDING SITE FOR RESIDUE ATP B 2 source : AC4 14) chain A residue 549 type sequence S description BINDING SITE FOR RESIDUE ATP B 2 source : AC4 15) chain A residue 550 type sequence G description BINDING SITE FOR RESIDUE ATP B 2 source : AC4 16) chain A residue 551 type sequence G description BINDING SITE FOR RESIDUE ATP B 2 source : AC4 17) chain A residue 552 type sequence Q description BINDING SITE FOR RESIDUE ATP B 2 source : AC4 18) chain A residue 466 type BINDING sequence S description BINDING => ECO:0000269|PubMed:20150177, ECO:0007744|PDB:2PZE, ECO:0007744|PDB:2PZF, ECO:0007744|PDB:2PZG source Swiss-Prot : SWS_FT_FI2 19) chain A residue 493 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS source Swiss-Prot : SWS_FT_FI4 20) chain A residue 401 type BINDING sequence W description BINDING => ECO:0000269|PubMed:15528182, ECO:0000269|PubMed:20150177, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:1XMJ, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS, ECO:0007744|PDB:2BBT, ECO:0007744|PDB:2PZE, ECO:0007744|PDB:2PZF, ECO:0007744|PDB:2PZG source Swiss-Prot : SWS_FT_FI1 21) chain A residue 458 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434, ECO:0000269|PubMed:15528182, ECO:0007744|PDB:1XMI, ECO:0007744|PDB:1XMJ, ECO:0007744|PDB:2BBO, ECO:0007744|PDB:2BBS, ECO:0007744|PDB:2BBT source Swiss-Prot : SWS_FT_FI3 22) chain A residue 548-562 type prosite sequence LSGGQRARISLARAV description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRARISLARAV source prosite : PS00211 23) chain A residue 549 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI5 24) chain A residue 524 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:22119790 source Swiss-Prot : SWS_FT_FI6

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