|
eF-site ID
|
2px7-A |
PDB Code
|
2px7 |
Chain
|
A |
|
click to enlarge
|
|
Title
|
Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase from Thermus thermophilus HB8 |
Classification
|
TRANSFERASE |
Compound
|
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
Source
|
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (ISPD_THET8) |
|
Sequence
|
A: |
MEVSVLIPAAGGPKAFLQVGGRTLLEWTLAAFRDAAEVLV
ALPPGAEPPKGLGAVFLEGGATRQASVARLLEAASLPLVL
VHDVARPFVSRGLVARVLEAAQRSGAAVPVLPVPDTLMAP
EGEAYGRVVPREAFRLVQTPQGFFTALLREAHAYARRKGL
EASDDAQLVQALGYPVALVEGEATAFKITHPQDLVLAEAL
ARV
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
86-93 |
type |
prosite |
sequence |
VLVHDVAR
|
description |
ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VLVHDVAR
|
source |
prosite : PS01295
|
|
2)
|
chain |
A |
residue |
21 |
type |
SITE |
sequence |
K
|
description |
Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00108
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
A |
residue |
138 |
type |
SITE |
sequence |
R
|
description |
Positions MEP for the nucleophilic attack => ECO:0000255|HAMAP-Rule:MF_00108
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
A |
residue |
194 |
type |
SITE |
sequence |
K
|
description |
Positions MEP for the nucleophilic attack => ECO:0000255|HAMAP-Rule:MF_00108
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|