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|
eF-site ID
|
2psq-B |
|
PDB Code
|
2psq |
|
Chain
|
B |
|
click to enlarge
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Title
|
Crystal Structure of Unphosphorylated Unactivated Wild Type FGF Receptor 2 (FGFR2) Kinase Domain |
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Classification
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TRANSFERASE |
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Compound
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Fibroblast growth factor receptor 2 |
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Source
|
Homo sapiens (Human) (FGFR2_HUMAN) |
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Sequence
|
B: |
ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDPK
EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLRARRPPGEEQMTF
KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM
KIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVY
THQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI
LTLTTN
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Description
|
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Functional site
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|
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1)
|
chain |
B |
| residue |
626 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19060208
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
B |
| residue |
487 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
B |
| residue |
517 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
B |
| residue |
565 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
B |
| residue |
571 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:19060208
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
B |
| residue |
656 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
7)
|
chain |
B |
| residue |
657 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:17803937, ECO:0000269|PubMed:19060208, ECO:0000269|PubMed:19410646
|
| source |
Swiss-Prot : SWS_FT_FI4
|
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|