eF-site/Summary 2psq-A

eF-site ID	2psq-A
PDB Code	2psq
Chain	A

click to enlarge

Title	Crystal Structure of Unphosphorylated Unactivated Wild Type FGF Receptor 2 (FGFR2) Kinase Domain
Classification	TRANSFERASE
Compound	Fibroblast growth factor receptor 2
Source	Homo sapiens (Human) (FGFR2_HUMAN)

Sequence	A:	LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI INLLGACTQDGPLYVIVEYASKGNLREYLRARRPPPEEQM TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN VMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDR VYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD RILTLTT

Description

Functional site


1)	chain	A
	residue	626
	type	ACT_SITE
	sequence	D
	description	Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10028, ECO:0000269\|PubMed:19060208
	source	Swiss-Prot : SWS_FT_FI1

2)	chain	A
	residue	487
	type	BINDING
	sequence	L
	description	BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000269\|PubMed:19060208
	source	Swiss-Prot : SWS_FT_FI2

3)	chain	A
	residue	517
	type	BINDING
	sequence	K
	description	BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000269\|PubMed:19060208
	source	Swiss-Prot : SWS_FT_FI2

4)	chain	A
	residue	565
	type	BINDING
	sequence	E
	description	BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000269\|PubMed:19060208
	source	Swiss-Prot : SWS_FT_FI2

5)	chain	A
	residue	571
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000269\|PubMed:19060208
	source	Swiss-Prot : SWS_FT_FI2

6)	chain	A
	residue	487-517
	type	prosite
	sequence	LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVK
	description	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGCFGQVVmAeavgidkdkpkeavt...VAVK
	source	prosite : PS00107

7)	chain	A
	residue	622-634
	type	prosite
	sequence	CIHRDLAARNVLV
	description	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV
	source	prosite : PS00109

8)	chain	A
	residue	656
	type	MOD_RES
	sequence	Y
	description	Phosphotyrosine; by autocatalysis => ECO:0000269\|PubMed:17803937, ECO:0000269\|PubMed:19060208, ECO:0000269\|PubMed:19410646
	source	Swiss-Prot : SWS_FT_FI4

9)	chain	A
	residue	657
	type	MOD_RES
	sequence	Y
	description	Phosphotyrosine; by autocatalysis => ECO:0000269\|PubMed:17803937, ECO:0000269\|PubMed:19060208, ECO:0000269\|PubMed:19410646
	source	Swiss-Prot : SWS_FT_FI4