eF-site ID 2pob-AB PDB Code 2pob Chain A, B click to enlarge Title PPARgamma Ligand binding domain complexed with a farglitazar analogue gw4709 Classification GENE REGULATION Compound Peroxisome proliferator-activated receptor gamma Source null (PPARG_HUMAN) Sequence A:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKKSPFVI YDMNSLMMGEDKIKKEVAIRIFQGCQFRSVEAVQEITEYA KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVL ISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELD DSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTE TDMSLHPLLQEIYKD B:  PESADLRALAKHLYDSYIKSFPLTKAKARAILTGSPFVIY DMNSLMMGQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIP GFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEG QGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDL AIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLN HPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETLHP LLQEIYK Description Functional site 1) chain A residue 282 type sequence F description BINDING SITE FOR RESIDUE GW4 A 478 source : AC1 2) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE GW4 A 478 source : AC1 3) chain A residue 286 type sequence Q description BINDING SITE FOR RESIDUE GW4 A 478 source : AC1 4) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE GW4 A 478 source : AC1 5) chain A residue 323 type sequence H description BINDING SITE FOR RESIDUE GW4 A 478 source : AC1 6) chain A residue 326 type sequence I description BINDING SITE FOR RESIDUE GW4 A 478 source : AC1 7) chain A residue 341 type sequence I description BINDING SITE FOR RESIDUE GW4 A 478 source : AC1 8) chain A residue 360 type sequence F description BINDING SITE FOR RESIDUE GW4 A 478 source : AC1 9) chain A residue 363 type sequence F description BINDING SITE FOR RESIDUE GW4 A 478 source : AC1 10) chain A residue 364 type sequence M description BINDING SITE FOR RESIDUE GW4 A 478 source : AC1 11) chain A residue 449 type sequence H description BINDING SITE FOR RESIDUE GW4 A 478 source : AC1 12) chain A residue 469 type sequence L description BINDING SITE FOR RESIDUE GW4 A 478 source : AC1 13) chain A residue 473 type sequence Y description BINDING SITE FOR RESIDUE GW4 A 478 source : AC1 14) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE GOL B 478 source : AC2 15) chain B residue 341 type sequence I description BINDING SITE FOR RESIDUE GOL B 478 source : AC2 16) chain B residue 342 type sequence S description BINDING SITE FOR RESIDUE GOL B 478 source : AC2 17) chain A residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 18) chain B residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 20) chain B residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 21) chain A residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 22) chain A residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 23) chain A residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 24) chain A residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 25) chain B residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 26) chain B residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1

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