eF-site ID 2pgn-AB PDB Code 2pgn Chain A, B click to enlarge Title The crystal structure of FAD and ThDP-dependent Cyclohexane-1,2-dione Hydrolase in Complex with Cyclohexane-1,2-dione Classification HYDROLASE Compound Cyclohexane-1,2-dione Hydrolase (Cdh) Source ORGANISM_SCIENTIFIC: Azoarcus sp.; Sequence A:  AIKRGADLIVEALEEYGTEQVVGFIGHTSHFVADAFSKSH LGKRVINPATELGGAWMVNGYNYVKDRSAAVGAWHCVGNL LLHAAMQEARTGRIPAVHIGLNSDGRLAGRSEAAQQVPWQ SFTPIARSTQRVERLDKVGEAIHEAFRVAEGHPAGPAYVD IPFDLTADQIDDKALVPRGATRAKSVLHAPNEDVREAAAQ LVAAKNPVILAGGGVARSGGSEALLKLAEMVGVPVVTTST GAGVFPETHALAMGSAGFCGWKSANDMMAAADFVLVLGSR LSDWGIAQGYITKMPKFVHVDTDPAVLGTFYFPLLSVVAD AKTFMEQLIEVLPGTSGFKAVRYQERENFRQATEFRAAWD GWVREQESGDGMPASMFRAMAEVRKVQRPEDIIVTDIGNH TLPMFGGAILQRPRRLVTSMAEGILGCGFPMALGAQLAEP NSRVFLGTGDGALYYHFNEFRVAVEHKLPVITMVFTNESY GANWTLMNHQFGQNNWTEFMNPDWVGIAKAFGAYGESVRE TGDIAGALQRAIDSGKPALIEIPVSKTQGLASDPVGGVGP NLLLKGREIPVDTGGSMYPGENLLHLK B:  AIKRGADLIVEALEEYGTEQVVGFIGHTSHFVADAFSKSH LGKRVINPATELGGAWMVNGYNYVKDRSAAVGAWHCVGNL LLHAAMQEARTGRIPAVHIGLNSDGRLAGRSEAAQQVPWQ SFTPIARSTQRVERLDKVGEAIHEAFRVAEGHPAGPAYVD IPFDLTADQIDDKALVPRGATRAKSVLHAPNEDVREAAAQ LVAAKNPVILAGGGVARSGGSEALLKLAEMVGVPVVTTST GAGVFPETHALAMGSAGFCGWKSANDMMAAADFVLVLGSR LSDWGIAQGYITKMPKFVHVDTDPAVLGTFYFPLLSVVAD AKTFMEQLIEVLPGTSGFKAVRYQERENFRQATEFRAAWD GWVREQESGDGMPASMFRAMAEVRKVQRPEDIIVTDIGNH TLPMFGGAILQRPRRLVTSMAEGILGCGFPMALGAQLAEP NSRVFLGTGDGALYYHFNEFRVAVEHKLPVITMVFTNESY GANWTLMNHQFGQNNWTEFMNPDWVGIAKAFGAYGESVRE TGDIAGALQRAIDSGKPALIEIPVSKTQGLASDPVGGVGP NLLLKGREIPVDTGGSMYPGENLLHLK Description Functional site 1) chain A residue 451 type sequence D description BINDING SITE FOR RESIDUE MG A 610 source : AC1 2) chain A residue 478 type sequence N description BINDING SITE FOR RESIDUE MG A 610 source : AC1 3) chain A residue 480 type sequence S description BINDING SITE FOR RESIDUE MG A 610 source : AC1 4) chain B residue 451 type sequence D description BINDING SITE FOR RESIDUE MG B 611 source : AC2 5) chain B residue 478 type sequence N description BINDING SITE FOR RESIDUE MG B 611 source : AC2 6) chain B residue 480 type sequence S description BINDING SITE FOR RESIDUE MG B 611 source : AC2 7) chain A residue 185 type sequence K description BINDING SITE FOR RESIDUE P6G A 646 source : AC3 8) chain A residue 188 type sequence L description BINDING SITE FOR RESIDUE P6G A 646 source : AC3 9) chain A residue 303 type sequence T description BINDING SITE FOR RESIDUE P6G A 646 source : AC3 10) chain A residue 305 type sequence P description BINDING SITE FOR RESIDUE P6G A 646 source : AC3 11) chain A residue 153 type sequence H description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 12) chain A residue 213 type sequence G description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 13) chain A residue 214 type sequence G description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 14) chain A residue 215 type sequence G description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 15) chain A residue 218 type sequence R description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 16) chain A residue 219 type sequence S description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 17) chain A residue 239 type sequence T description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 18) chain A residue 240 type sequence S description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 19) chain A residue 241 type sequence T description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 20) chain A residue 257 type sequence A description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 21) chain A residue 258 type sequence G description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 22) chain A residue 259 type sequence F description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 23) chain A residue 260 type sequence C description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 24) chain A residue 261 type sequence G description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 25) chain A residue 279 type sequence G description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 26) chain A residue 280 type sequence S description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 27) chain A residue 281 type sequence R description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 28) chain A residue 282 type sequence L description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 29) chain A residue 283 type sequence S description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 30) chain A residue 285 type sequence W description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 31) chain A residue 286 type sequence G description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 32) chain A residue 302 type sequence D description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 33) chain A residue 303 type sequence T description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 34) chain A residue 304 type sequence D description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 35) chain A residue 320 type sequence A description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 36) chain A residue 321 type sequence D description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 37) chain A residue 322 type sequence A description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 38) chain A residue 420 type sequence S description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 39) chain A residue 421 type sequence M description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 40) chain A residue 422 type sequence A description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 41) chain A residue 424 type sequence G description BINDING SITE FOR RESIDUE FAD A 612 source : AC4 42) chain B residue 153 type sequence H description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 43) chain B residue 213 type sequence G description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 44) chain B residue 214 type sequence G description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 45) chain B residue 215 type sequence G description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 46) chain B residue 218 type sequence R description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 47) chain B residue 219 type sequence S description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 48) chain B residue 239 type sequence T description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 49) chain B residue 240 type sequence S description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 50) chain B residue 241 type sequence T description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 51) chain B residue 257 type sequence A description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 52) chain B residue 258 type sequence G description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 53) chain B residue 259 type sequence F description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 54) chain B residue 260 type sequence C description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 55) chain B residue 261 type sequence G description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 56) chain B residue 279 type sequence G description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 57) chain B residue 280 type sequence S description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 58) chain B residue 281 type sequence R description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 59) chain B residue 283 type sequence S description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 60) chain B residue 285 type sequence W description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 61) chain B residue 286 type sequence G description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 62) chain B residue 302 type sequence D description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 63) chain B residue 303 type sequence T description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 64) chain B residue 304 type sequence D description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 65) chain B residue 321 type sequence D description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 66) chain B residue 322 type sequence A description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 67) chain B residue 406 type sequence F description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 68) chain B residue 420 type sequence S description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 69) chain B residue 421 type sequence M description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 70) chain B residue 422 type sequence A description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 71) chain B residue 424 type sequence G description BINDING SITE FOR RESIDUE FAD B 613 source : AC5 72) chain A residue 398 type sequence I description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 73) chain A residue 399 type sequence G description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 74) chain A residue 400 type sequence N description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 75) chain A residue 401 type sequence H description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 76) chain A residue 424 type sequence G description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 77) chain A residue 426 type sequence L description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 78) chain A residue 450 type sequence G description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 79) chain A residue 451 type sequence D description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 80) chain A residue 452 type sequence G description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 81) chain A residue 453 type sequence A description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 82) chain A residue 456 type sequence Y description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 83) chain A residue 478 type sequence N description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 84) chain A residue 480 type sequence S description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 85) chain A residue 481 type sequence Y description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 86) chain A residue 482 type sequence G description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 87) chain A residue 483 type sequence A description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 88) chain A residue 484 type sequence N description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 89) chain B residue 26 type sequence I description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 90) chain B residue 52 type sequence E description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 91) chain B residue 76 type sequence H description BINDING SITE FOR RESIDUE TPP A 614 source : AC6 92) chain A residue 26 type sequence I description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 93) chain A residue 52 type sequence E description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 94) chain A residue 76 type sequence H description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 95) chain B residue 398 type sequence I description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 96) chain B residue 399 type sequence G description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 97) chain B residue 400 type sequence N description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 98) chain B residue 401 type sequence H description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 99) chain B residue 424 type sequence G description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 100) chain B residue 426 type sequence L description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 101) chain B residue 450 type sequence G description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 102) chain B residue 451 type sequence D description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 103) chain B residue 452 type sequence G description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 104) chain B residue 453 type sequence A description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 105) chain B residue 456 type sequence Y description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 106) chain B residue 478 type sequence N description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 107) chain B residue 480 type sequence S description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 108) chain B residue 481 type sequence Y description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 109) chain B residue 482 type sequence G description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 110) chain B residue 483 type sequence A description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 111) chain B residue 484 type sequence N description BINDING SITE FOR RESIDUE TPP B 615 source : AC7 112) chain A residue 285 type sequence W description BINDING SITE FOR RESIDUE CXO B 601 source : AC8 113) chain A residue 484 type sequence N description BINDING SITE FOR RESIDUE CXO B 601 source : AC8 114) chain B residue 27 type sequence G description BINDING SITE FOR RESIDUE CXO B 601 source : AC8 115) chain B residue 28 type sequence H description BINDING SITE FOR RESIDUE CXO B 601 source : AC8 116) chain B residue 76 type sequence H description BINDING SITE FOR RESIDUE CXO B 601 source : AC8 117) chain B residue 116 type sequence Q description BINDING SITE FOR RESIDUE CXO B 601 source : AC8 118) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE CXO A 1601 source : AC9 119) chain A residue 28 type sequence H description BINDING SITE FOR RESIDUE CXO A 1601 source : AC9 120) chain A residue 76 type sequence H description BINDING SITE FOR RESIDUE CXO A 1601 source : AC9 121) chain A residue 116 type sequence Q description BINDING SITE FOR RESIDUE CXO A 1601 source : AC9 122) chain B residue 285 type sequence W description BINDING SITE FOR RESIDUE CXO A 1601 source : AC9 123) chain B residue 484 type sequence N description BINDING SITE FOR RESIDUE CXO A 1601 source : AC9 124) chain A residue 120 type sequence W description BINDING SITE FOR RESIDUE P6G A 641 source : BC1 125) chain A residue 132 type sequence R description BINDING SITE FOR RESIDUE P6G A 641 source : BC1 126) chain B residue 91 type sequence R description BINDING SITE FOR RESIDUE P6G B 642 source : BC2 127) chain B residue 124 type sequence T description BINDING SITE FOR RESIDUE P6G B 642 source : BC2 128) chain B residue 125 type sequence P description BINDING SITE FOR RESIDUE P6G B 642 source : BC2 129) chain B residue 127 type sequence A description BINDING SITE FOR RESIDUE P6G B 642 source : BC2 130) chain B residue 128 type sequence R description BINDING SITE FOR RESIDUE P6G B 642 source : BC2 131) chain B residue 120 type sequence W description BINDING SITE FOR RESIDUE P6G B 643 source : BC3 132) chain B residue 132 type sequence R description BINDING SITE FOR RESIDUE P6G B 643 source : BC3 133) chain A residue 510 type sequence K description BINDING SITE FOR RESIDUE P6G A 644 source : BC4 134) chain A residue 511 type sequence A description BINDING SITE FOR RESIDUE P6G A 644 source : BC4 135) chain B residue 504 type sequence D description BINDING SITE FOR RESIDUE P6G A 644 source : BC4 136) chain A residue 91 type sequence R description BINDING SITE FOR RESIDUE P6G A 645 source : BC5 137) chain A residue 124 type sequence T description BINDING SITE FOR RESIDUE P6G A 645 source : BC5 138) chain A residue 125 type sequence P description BINDING SITE FOR RESIDUE P6G A 645 source : BC5 139) chain A residue 128 type sequence R description BINDING SITE FOR RESIDUE P6G A 645 source : BC5 140) chain A residue 466 type sequence E description BINDING SITE FOR RESIDUE P6G A 647 source : BC6 141) chain B residue 16 type sequence E description BINDING SITE FOR RESIDUE P6G A 647 source : BC6 142) chain B residue 41 type sequence H description BINDING SITE FOR RESIDUE P6G A 647 source : BC6 143) chain B residue 499 type sequence E description BINDING SITE FOR RESIDUE P6G A 647 source : BC6 144) chain B residue 501 type sequence M description BINDING SITE FOR RESIDUE P6G A 647 source : BC6 145) chain B residue 389 type sequence R description BINDING SITE FOR RESIDUE P6G B 648 source : BC7 146) chain B residue 441 type sequence P description BINDING SITE FOR RESIDUE P6G B 648 source : BC7 147) chain B residue 443 type sequence S description BINDING SITE FOR RESIDUE P6G B 648 source : BC7 148) chain B residue 444 type sequence R description BINDING SITE FOR RESIDUE P6G B 648 source : BC7 149) chain B residue 363 type sequence W description BINDING SITE FOR RESIDUE P6G B 649 source : BC8 150) chain B residue 366 type sequence E description BINDING SITE FOR RESIDUE P6G B 649 source : BC8 151) chain B residue 367 type sequence Q description BINDING SITE FOR RESIDUE P6G B 649 source : BC8 152) chain B residue 533 type sequence I description BINDING SITE FOR RESIDUE P6G B 649 source : BC8 153) chain B residue 534 type sequence D description BINDING SITE FOR RESIDUE P6G B 649 source : BC8 154) chain B residue 536 type sequence G description BINDING SITE FOR RESIDUE P6G B 649 source : BC8 155) chain B residue 546 type sequence S description BINDING SITE FOR RESIDUE P6G B 649 source : BC8 156) chain B residue 554 type sequence D description BINDING SITE FOR RESIDUE P6G B 649 source : BC8

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