eF-site ID 2pad-A
PDB Code 2pad
Chain A

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Title BINDING OF CHLOROMETHYL KETONE SUBSTRATE ANALOGUES TO CRYSTALLINE PAPAIN
Classification HYDROLASE (SULFHYDRYL PROTEINASE)
Compound PAPAIN
Source Carica papaya (Papaya) (PAPA1_CARPA)
Sequence A:  IPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKI
RTGNLNQYSEQELLDCDRRSYGCNGGYPWSALQLVAQYGI
HYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNQGA
LLYSIANQPVSVVLQAAGKDFQLYRGGIFVGPCGNKVDHA
VAAVGYGPNYILIKNSWGTGWGENGYIRIKRGTGNSYGVC
GLYTSSFYPVKN
Description


Functional site

1) chain A
residue 19
type
sequence Q
description BINDING SITE FOR RESIDUE CYS A 213
source : AC1

2) chain A
residue 25
type
sequence C
description BINDING SITE FOR RESIDUE CYS A 213
source : AC1

3) chain A
residue 136
type
sequence A
description BINDING SITE FOR RESIDUE CYS A 213
source : AC1

4) chain A
residue 159
type
sequence H
description BINDING SITE FOR RESIDUE CYS A 213
source : AC1

5) chain A
residue 19
type catalytic
sequence Q
description 174
source MCSA : MCSA1

6) chain A
residue 25
type catalytic
sequence C
description 174
source MCSA : MCSA1

7) chain A
residue 159
type catalytic
sequence H
description 174
source MCSA : MCSA1

8) chain A
residue 175
type catalytic
sequence N
description 174
source MCSA : MCSA1

9) chain A
residue 175
type ACT_SITE
sequence N
description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090, ECO:0000269|PubMed:5681232, ECO:0000269|PubMed:6502713, ECO:0000269|PubMed:952885, ECO:0007744|PDB:1PAD, ECO:0007744|PDB:9PAP
source Swiss-Prot : SWS_FT_FI3

10) chain A
residue 25
type BINDING
sequence C
description covalent => ECO:0000269|PubMed:8416808, ECO:0007744|PDB:1POP
source Swiss-Prot : SWS_FT_FI4

11) chain A
residue 159
type ACT_SITE
sequence H
description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089, ECO:0000269|PubMed:6502713, ECO:0000269|PubMed:952885, ECO:0007744|PDB:1PAD, ECO:0007744|PDB:9PAP
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 25
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10088, ECO:0000269|PubMed:5681232, ECO:0000269|PubMed:6502713, ECO:0000269|PubMed:952885, ECO:0000305|PubMed:1860874, ECO:0007744|PDB:1PAD, ECO:0007744|PDB:9PAP
source Swiss-Prot : SWS_FT_FI1

13) chain A
residue 19-30
type prosite
sequence QGSCGSCWAFSA
description THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGsCGSCWAfSA
source prosite : PS00139

14) chain A
residue 157-167
type prosite
sequence VDHAVAAVGYG
description THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. VDHAVAAVGYG
source prosite : PS00639

15) chain A
residue 170-189
type prosite
sequence YILIKNSWGTGWGENGYIRI
description THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YILiKNSWgtgWGenGYIrI
source prosite : PS00640


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