eF-site ID 2p6b-C
PDB Code 2p6b
Chain C

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Title Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide
Classification HYDROLASE/HYDROLASE REGULATOR
Compound PVIVIT 14-mer Peptide
Source (2P6B)
Sequence C:  TDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKE
GRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHG
QFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYL
WALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSER
VYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIR
KLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTV
RGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRK
SQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQ
FNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLN
Description


Functional site

1) chain C
residue 118
type
sequence D
description BINDING SITE FOR RESIDUE ZN C 512
source : AC8

2) chain C
residue 150
type
sequence N
description BINDING SITE FOR RESIDUE ZN C 512
source : AC8

3) chain C
residue 199
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 512
source : AC8

4) chain C
residue 281
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 512
source : AC8

5) chain C
residue 90
type
sequence D
description BINDING SITE FOR RESIDUE FE C 513
source : AC9

6) chain C
residue 92
type
sequence H
description BINDING SITE FOR RESIDUE FE C 513
source : AC9

7) chain C
residue 118
type
sequence D
description BINDING SITE FOR RESIDUE FE C 513
source : AC9

8) chain C
residue 92
type
sequence H
description BINDING SITE FOR RESIDUE PO4 C 514
source : BC1

9) chain C
residue 118
type
sequence D
description BINDING SITE FOR RESIDUE PO4 C 514
source : BC1

10) chain C
residue 122
type
sequence R
description BINDING SITE FOR RESIDUE PO4 C 514
source : BC1

11) chain C
residue 150
type
sequence N
description BINDING SITE FOR RESIDUE PO4 C 514
source : BC1

12) chain C
residue 151
type
sequence H
description BINDING SITE FOR RESIDUE PO4 C 514
source : BC1

13) chain C
residue 254
type
sequence R
description BINDING SITE FOR RESIDUE PO4 C 514
source : BC1

14) chain C
residue 281
type
sequence H
description BINDING SITE FOR RESIDUE PO4 C 514
source : BC1

15) chain C
residue 90
type catalytic
sequence D
description 406
source MCSA : MCSA2

16) chain C
residue 281
type catalytic
sequence H
description 406
source MCSA : MCSA2

17) chain C
residue 92
type catalytic
sequence H
description 406
source MCSA : MCSA2

18) chain C
residue 118
type catalytic
sequence D
description 406
source MCSA : MCSA2

19) chain C
residue 121
type catalytic
sequence D
description 406
source MCSA : MCSA2

20) chain C
residue 122
type catalytic
sequence R
description 406
source MCSA : MCSA2

21) chain C
residue 150
type catalytic
sequence N
description 406
source MCSA : MCSA2

22) chain C
residue 151
type catalytic
sequence H
description 406
source MCSA : MCSA2

23) chain C
residue 199
type catalytic
sequence H
description 406
source MCSA : MCSA2

24) chain C
residue 254
type catalytic
sequence R
description 406
source MCSA : MCSA2

25) chain C
residue 199
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:8524402, ECO:0000312|PDB:6NUC, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
source Swiss-Prot : SWS_FT_FI2

26) chain C
residue 281
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:8524402, ECO:0000312|PDB:6NUC, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
source Swiss-Prot : SWS_FT_FI2

27) chain C
residue 224
type MOD_RES
sequence Y
description 3'-nitrotyrosine => ECO:0000250|UniProtKB:P63328
source Swiss-Prot : SWS_FT_FI5


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