eF-site ID 2p6b-A PDB Code 2p6b Chain A click to enlarge Title Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide Classification HYDROLASE/HYDROLASE REGULATOR Compound PVIVIT 14-mer Peptide Source (2P6B) Sequence A:  TDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKE GRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHG QFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYL WALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSER VYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIR KLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTV RGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRK SQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQ FNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLN Description Functional site 1) chain A residue 118 type sequence D description BINDING SITE FOR RESIDUE ZN A 509 source : AC1 2) chain A residue 150 type sequence N description BINDING SITE FOR RESIDUE ZN A 509 source : AC1 3) chain A residue 199 type sequence H description BINDING SITE FOR RESIDUE ZN A 509 source : AC1 4) chain A residue 281 type sequence H description BINDING SITE FOR RESIDUE ZN A 509 source : AC1 5) chain A residue 90 type sequence D description BINDING SITE FOR RESIDUE FE A 510 source : AC2 6) chain A residue 92 type sequence H description BINDING SITE FOR RESIDUE FE A 510 source : AC2 7) chain A residue 118 type sequence D description BINDING SITE FOR RESIDUE FE A 510 source : AC2 8) chain A residue 92 type sequence H description BINDING SITE FOR RESIDUE PO4 A 511 source : AC3 9) chain A residue 118 type sequence D description BINDING SITE FOR RESIDUE PO4 A 511 source : AC3 10) chain A residue 122 type sequence R description BINDING SITE FOR RESIDUE PO4 A 511 source : AC3 11) chain A residue 150 type sequence N description BINDING SITE FOR RESIDUE PO4 A 511 source : AC3 12) chain A residue 151 type sequence H description BINDING SITE FOR RESIDUE PO4 A 511 source : AC3 13) chain A residue 254 type sequence R description BINDING SITE FOR RESIDUE PO4 A 511 source : AC3 14) chain A residue 281 type sequence H description BINDING SITE FOR RESIDUE PO4 A 511 source : AC3 15) chain A residue 224 type MOD_RES sequence Y description 3'-nitrotyrosine => ECO:0000250|UniProtKB:P63328 source Swiss-Prot : SWS_FT_FI5 16) chain A residue 147-152 type prosite sequence LRGNHE description SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE source prosite : PS00125 17) chain A residue 90 type catalytic sequence D description 406 source MCSA : MCSA1 18) chain A residue 92 type catalytic sequence H description 406 source MCSA : MCSA1 19) chain A residue 118 type catalytic sequence D description 406 source MCSA : MCSA1 20) chain A residue 121 type catalytic sequence D description 406 source MCSA : MCSA1 21) chain A residue 122 type catalytic sequence R description 406 source MCSA : MCSA1 22) chain A residue 150 type catalytic sequence N description 406 source MCSA : MCSA1 23) chain A residue 151 type catalytic sequence H description 406 source MCSA : MCSA1 24) chain A residue 199 type catalytic sequence H description 406 source MCSA : MCSA1 25) chain A residue 254 type catalytic sequence R description 406 source MCSA : MCSA1 26) chain A residue 281 type catalytic sequence H description 406 source MCSA : MCSA1

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