eF-site ID 2p5t-ABCDEFGHX PDB Code 2p5t Chain A, B, C, D, E, F, G, H, X click to enlarge Title Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae Classification TRANSCRIPTION REGULATOR Compound fragment of PezA helix-turn-helix motif Source Streptococcus pneumoniae (2P5T) Sequence A:  LNPVEDYELTLKIEIVKERGANLLSRLYRYQDSQGISIDD ESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIE RMLEISEKRMVA B:  IQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSG AGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQEY GKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTVD VPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEELY IINPNQHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSC VYDSKENTTSAADVLQELFFGEWSQVEKEMLQVGEKRLNE LLEK C:  MLNPVEDYELTLKIEIVKERGANLLSRLYRYQDSQGISID DESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGI ERMLEISEKRMVA D:  MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQ SGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRT VDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE LYIINPNQPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQ RDRSCVYDSKENTTSAADVLQELFFGEWSQVEKEMLQVGE KRLNELL E:  DKMLNPVEDYELTLKIEIVKERGANLLSRLYRYQDSQGIS IDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLD GIERMLEISEKRMVA F:  EIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQS GAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQE YGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTV DVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEEL YIINDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDS KENTTSAADVLQELFFGEWSQVEKEMLQVGEKRLNELLEK G:  MLNPVEDYELTLKIEIVKERGANLLSRLYRYQDSQGISID DESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGI ERMLEISEKRMVA H:  MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQ SGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRT VDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE LYIINPDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVY DSKENTTSAADVLQELFFGEWSQVEKEMLQVGEKRLNELL EK X:  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX Description Functional site 1) chain B residue 35-48 type prosite sequence ILLGGQSGAGKTTI description SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. ILLgGQSGAGKttI source prosite : PS00675 2) chain B residue 66 type ACT_SITE sequence D description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 3) chain D residue 66 type ACT_SITE sequence D description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 4) chain F residue 66 type ACT_SITE sequence D description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 5) chain H residue 66 type ACT_SITE sequence D description Proton acceptor => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 6) chain B residue 39 type BINDING sequence G description BINDING => ECO:0000305|PubMed:17488720 source Swiss-Prot : SWS_FT_FI2 7) chain D residue 39 type BINDING sequence G description BINDING => ECO:0000305|PubMed:17488720 source Swiss-Prot : SWS_FT_FI2 8) chain F residue 39 type BINDING sequence G description BINDING => ECO:0000305|PubMed:17488720 source Swiss-Prot : SWS_FT_FI2 9) chain H residue 39 type BINDING sequence G description BINDING => ECO:0000305|PubMed:17488720 source Swiss-Prot : SWS_FT_FI2

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