eF-site ID 2p5n-B PDB Code 2p5n Chain B click to enlarge Title Crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase in complex with coenzyme NADPH Classification OXIDOREDUCTASE Compound Aldo-keto reductase family 1, member C21 Source (Q6P8V0_MOUSE) Sequence B:  MNSKCHCVILNDGNFIPVLGFGTALPLECPKSKAKELTKI AIDAGFHHFDSASVYNTEDHVGEAIRSKIADGTVRREDIF YTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPM ALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLT KSIGVSNFNYRQLEMILNKPGLKYKPVCNQVECHPYLNQM KLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPV LGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKEN MQVFEFQLSSEDMKVLDGLNRNMRYIPAAIFKGHPNWPFL DEY Description Functional site 1) chain B residue 22 type sequence G description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 2) chain B residue 23 type sequence T description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 3) chain B residue 24 type sequence A description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 4) chain B residue 50 type sequence D description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 5) chain B residue 55 type sequence Y description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 6) chain B residue 84 type sequence K description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 7) chain B residue 117 type sequence H description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 8) chain B residue 166 type sequence S description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 9) chain B residue 167 type sequence N description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 10) chain B residue 190 type sequence Q description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 11) chain B residue 216 type sequence Y description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 12) chain B residue 217 type sequence G description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 13) chain B residue 218 type sequence V description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 14) chain B residue 219 type sequence L description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 15) chain B residue 220 type sequence G description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 16) chain B residue 221 type sequence T description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 17) chain B residue 222 type sequence Q description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 18) chain B residue 224 type sequence Y description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 19) chain B residue 236 type sequence L description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 20) chain B residue 253 type sequence A description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 21) chain B residue 269 type sequence N description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 22) chain B residue 270 type sequence T description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 23) chain B residue 271 type sequence S description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 24) chain B residue 272 type sequence L description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 25) chain B residue 273 type sequence K description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 26) chain B residue 276 type sequence R description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 27) chain B residue 279 type sequence E description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 28) chain B residue 280 type sequence N description BINDING SITE FOR RESIDUE NDP B 2350 source : AC2 29) chain B residue 55 type sequence Y description BINDING SITE FOR RESIDUE MPD B 2001 source : AC4 30) chain B residue 224 type sequence Y description BINDING SITE FOR RESIDUE MPD B 2001 source : AC4 31) chain B residue 227 type sequence W description BINDING SITE FOR RESIDUE MPD B 2001 source : AC4 32) chain B residue 55 type ACT_SITE sequence Y description Proton donor source Swiss-Prot : SWS_FT_FI1 33) chain B residue 84 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 34) chain B residue 190 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 35) chain B residue 216 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 270 type BINDING sequence T description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 20 type BINDING sequence G description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 50 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 39) chain B residue 166 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17909281, ECO:0000269|PubMed:19237748 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 31 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 41) chain B residue 117 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI3

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