eF-site ID 2p2d-A PDB Code 2p2d Chain A click to enlarge Title Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia coli L-Asparaginase I Classification TRANSFERASE Compound L-ASPARAGINASE I Source Escherichia coli (strain K12) (ASPG1_ECOLI) Sequence A:  QKKSIYVAYTGGTIGMQRSEQGYIPVSGHLQRQLALMPEF HRPEMPDFTIHEYTPLMDSSDMTPEDWQHIAEDIKAHYDD YDGFVILHGTDTMAYTASALSFMLENLGKPVIVTGSQIPL AELRSDGQINLLNALYVAANYPINEVTLFFNNRLYRGNRT TKAHADGFDAFASPNLPPLLEAGIHIRRLNTPPAPHGEGE LIVHPITPQPIGVVTIYPGISADVVRNFLRQPVKALILRS YGVGNAPQNKAFLQELQEASDRGIVVVNLTQCMSGKVNMN ALAHAGVIGGADMTVEATLTKLHYLLSQELDTETIRKAMS QNLRGELTPD Description Functional site 1) chain A residue 102 type sequence S description BINDING SITE FOR RESIDUE GOL A 7001 source : AC1 2) chain A residue 105 type sequence L description BINDING SITE FOR RESIDUE GOL A 7001 source : AC1 3) chain A residue 107 type sequence N description BINDING SITE FOR RESIDUE GOL A 7001 source : AC1 4) chain A residue 108 type sequence L description BINDING SITE FOR RESIDUE GOL A 7001 source : AC1 5) chain A residue 196 type sequence P description BINDING SITE FOR RESIDUE GOL A 7001 source : AC1 6) chain A residue 331 type sequence R description BINDING SITE FOR RESIDUE GOL A 7001 source : AC1 7) chain A residue 240 type sequence R description BINDING SITE FOR RESIDUE GOL A 7004 source : AC4 8) chain A residue 271 type sequence T description BINDING SITE FOR RESIDUE GOL A 7004 source : AC4 9) chain A residue 273 type sequence C description BINDING SITE FOR RESIDUE GOL A 7004 source : AC4 10) chain A residue 300 type sequence M description BINDING SITE FOR RESIDUE GOL A 7004 source : AC4 11) chain A residue 302 type sequence V description BINDING SITE FOR RESIDUE GOL A 7004 source : AC4 12) chain A residue 13 type sequence G description BINDING SITE FOR RESIDUE GOL A 9001 source : AC9 13) chain A residue 58 type sequence M description BINDING SITE FOR RESIDUE GOL A 9001 source : AC9 14) chain A residue 60 type sequence S description BINDING SITE FOR RESIDUE GOL A 9001 source : AC9 15) chain A residue 90 type sequence G description BINDING SITE FOR RESIDUE GOL A 9001 source : AC9 16) chain A residue 91 type sequence T description BINDING SITE FOR RESIDUE GOL A 9001 source : AC9 17) chain A residue 92 type sequence D description BINDING SITE FOR RESIDUE GOL A 9001 source : AC9 18) chain A residue 8-16 type prosite sequence VAYTGGTIG description ASN_GLN_ASE_1 Asparaginase / glutaminase active site signature 1. VaYTGGTIG source prosite : PS00144 19) chain A residue 84-94 type prosite sequence GFVILHGTDTM description ASN_GLN_ASE_2 Asparaginase / glutaminase active site signature 2. GfVilHGTDTM source prosite : PS00917 20) chain A residue 14 type ACT_SITE sequence T description O-isoaspartyl threonine intermediate => ECO:0000255|PROSITE-ProRule:PRU10099, ECO:0000255|PROSITE-ProRule:PRU10100, ECO:0000269|PubMed:17451745 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 59 type BINDING sequence D description BINDING => ECO:0007744|PDB:2P2N source Swiss-Prot : SWS_FT_FI2 22) chain A residue 91 type BINDING sequence T description BINDING => ECO:0007744|PDB:2P2N source Swiss-Prot : SWS_FT_FI2 23) chain A residue 162 type BINDING sequence T description BINDING => ECO:0007744|PDB:2P2N source Swiss-Prot : SWS_FT_FI2 24) chain A residue 240 type BINDING sequence R description BINDING => ECO:0007744|PDB:2P2N source Swiss-Prot : SWS_FT_FI2 25) chain A residue 271 type BINDING sequence T description BINDING => ECO:0007744|PDB:2P2N source Swiss-Prot : SWS_FT_FI2

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