eF-site ID 2p0a-AB PDB Code 2p0a Chain A, B click to enlarge Title The crystal structure of human synapsin III (SYN3) in complex with AMPPNP Classification NEUROPEPTIDE Compound Synapsin-3 Source Homo sapiens (Human) (SYN3_HUMAN) Sequence A:  RPRILLVIDDAHTDWSKYFHGKKVNGEIEIRVEQAEFSEL NLAAYVTGGCMVDMQRSFKPDFILVRQHAYSMALGEDYRS LVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLG PEKFPLVEQTFFPNHKPMVTAPHFPVVVKLGHAHAGMGKI KVENQLDFQDITSVVAMAKTYATTEAFIDSKYDIRIQKIG SNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSC SEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVE EDRQLMADLVVSKMSQLP B:  RPRILLVIDDAHTDWSKYFHGKKVNGEIEIRVEQAEFSEL NLAAYVTGGCMVDMQRSFKPDFILVRQHAYSMALGEDYRS LVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLG PEKFPLVEQTFFPNHKPMVTAPHFPVVVKLGHAHAGMGKI KVENQLDFQDITSVVAMAKTYATTEAFIDSKYDIRIQKIG SNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSC SEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVE EDRQLMADLVVSKMSQLP Description Functional site 1) chain A residue 170 type sequence S description BINDING SITE FOR RESIDUE CL A 501 source : AC1 2) chain A residue 172 type sequence A description BINDING SITE FOR RESIDUE CL A 501 source : AC1 3) chain A residue 252 type sequence A description BINDING SITE FOR RESIDUE CL A 501 source : AC1 4) chain A residue 253 type sequence H description BINDING SITE FOR RESIDUE CL A 501 source : AC1 5) chain B residue 170 type sequence S description BINDING SITE FOR RESIDUE CL B 501 source : AC2 6) chain B residue 172 type sequence A description BINDING SITE FOR RESIDUE CL B 501 source : AC2 7) chain B residue 173 type sequence L description BINDING SITE FOR RESIDUE CL B 501 source : AC2 8) chain B residue 252 type sequence A description BINDING SITE FOR RESIDUE CL B 501 source : AC2 9) chain B residue 253 type sequence H description BINDING SITE FOR RESIDUE CL B 501 source : AC2 10) chain A residue 100 type sequence A description BINDING SITE FOR RESIDUE SO4 A 701 source : AC3 11) chain A residue 165 type sequence R description BINDING SITE FOR RESIDUE SO4 A 701 source : AC3 12) chain A residue 372 type sequence P description BINDING SITE FOR RESIDUE SO4 A 701 source : AC3 13) chain A residue 373 type sequence L description BINDING SITE FOR RESIDUE SO4 A 701 source : AC3 14) chain A residue 382 type sequence R description BINDING SITE FOR RESIDUE SO4 A 701 source : AC3 15) chain A residue 294 type sequence R description BINDING SITE FOR RESIDUE SO4 A 702 source : AC4 16) chain A residue 307 type sequence R description BINDING SITE FOR RESIDUE SO4 A 702 source : AC4 17) chain A residue 317 type sequence N description BINDING SITE FOR RESIDUE SO4 A 702 source : AC4 18) chain A residue 352 type sequence K description BINDING SITE FOR RESIDUE SO4 A 702 source : AC4 19) chain A residue 367 type sequence M description BINDING SITE FOR RESIDUE SO4 A 702 source : AC4 20) chain A residue 372 type sequence P description BINDING SITE FOR RESIDUE SO4 A 702 source : AC4 21) chain A residue 374 type sequence I description BINDING SITE FOR RESIDUE SO4 A 702 source : AC4 22) chain B residue 165 type sequence R description BINDING SITE FOR RESIDUE SO4 B 703 source : AC5 23) chain B residue 372 type sequence P description BINDING SITE FOR RESIDUE SO4 B 703 source : AC5 24) chain B residue 373 type sequence L description BINDING SITE FOR RESIDUE SO4 B 703 source : AC5 25) chain B residue 382 type sequence R description BINDING SITE FOR RESIDUE SO4 B 703 source : AC5 26) chain B residue 294 type sequence R description BINDING SITE FOR RESIDUE SO4 B 704 source : AC6 27) chain B residue 307 type sequence R description BINDING SITE FOR RESIDUE SO4 B 704 source : AC6 28) chain B residue 317 type sequence N description BINDING SITE FOR RESIDUE SO4 B 704 source : AC6 29) chain B residue 352 type sequence K description BINDING SITE FOR RESIDUE SO4 B 704 source : AC6 30) chain B residue 367 type sequence M description BINDING SITE FOR RESIDUE SO4 B 704 source : AC6 31) chain B residue 372 type sequence P description BINDING SITE FOR RESIDUE SO4 B 704 source : AC6 32) chain B residue 374 type sequence I description BINDING SITE FOR RESIDUE SO4 B 704 source : AC6 33) chain A residue 376 type sequence E description BINDING SITE FOR RESIDUE SO4 A 705 source : AC7 34) chain A residue 377 type sequence H description BINDING SITE FOR RESIDUE SO4 A 705 source : AC7 35) chain A residue 379 type sequence E description BINDING SITE FOR RESIDUE SO4 A 705 source : AC7 36) chain A residue 380 type sequence E description BINDING SITE FOR RESIDUE SO4 A 705 source : AC7 37) chain A residue 169 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 706 source : AC8 38) chain A residue 178 type sequence R description BINDING SITE FOR RESIDUE SO4 A 706 source : AC8 39) chain B residue 178 type sequence R description BINDING SITE FOR RESIDUE SO4 A 706 source : AC8 40) chain A residue 204 type sequence K description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 41) chain A residue 248 type sequence K description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 42) chain A residue 252 type sequence A description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 43) chain A residue 253 type sequence H description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 44) chain A residue 254 type sequence A description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 45) chain A residue 255 type sequence G description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 46) chain A residue 258 type sequence K description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 47) chain A residue 284 type sequence E description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 48) chain A residue 285 type sequence A description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 49) chain A residue 287 type sequence I description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 50) chain A residue 292 type sequence D description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 51) chain A residue 314 type sequence W description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 52) chain A residue 315 type sequence K description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 53) chain A residue 316 type sequence A description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 54) chain A residue 317 type sequence N description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 55) chain A residue 352 type sequence K description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 56) chain A residue 364 type sequence I description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 57) chain A residue 365 type sequence E description BINDING SITE FOR RESIDUE ANP A 707 source : AC9 58) chain B residue 204 type sequence K description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 59) chain B residue 248 type sequence K description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 60) chain B residue 252 type sequence A description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 61) chain B residue 253 type sequence H description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 62) chain B residue 254 type sequence A description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 63) chain B residue 255 type sequence G description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 64) chain B residue 258 type sequence K description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 65) chain B residue 284 type sequence E description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 66) chain B residue 285 type sequence A description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 67) chain B residue 287 type sequence I description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 68) chain B residue 292 type sequence D description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 69) chain B residue 314 type sequence W description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 70) chain B residue 315 type sequence K description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 71) chain B residue 316 type sequence A description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 72) chain B residue 317 type sequence N description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 73) chain B residue 352 type sequence K description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 74) chain B residue 364 type sequence I description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 75) chain B residue 365 type sequence E description BINDING SITE FOR RESIDUE ANP B 705 source : BC1 76) chain A residue 226 type sequence V description BINDING SITE FOR RESIDUE EDO A 601 source : BC2 77) chain A residue 227 type sequence E description BINDING SITE FOR RESIDUE EDO A 601 source : BC2 78) chain A residue 362 type sequence Y description BINDING SITE FOR RESIDUE EDO A 601 source : BC2 79) chain A residue 259 type sequence I description BINDING SITE FOR RESIDUE EDO A 602 source : BC3 80) chain A residue 260 type sequence K description BINDING SITE FOR RESIDUE EDO A 602 source : BC3 81) chain A residue 261 type sequence V description BINDING SITE FOR RESIDUE EDO A 602 source : BC3 82) chain A residue 262 type sequence E description BINDING SITE FOR RESIDUE EDO A 602 source : BC3 83) chain A residue 266 type sequence D description BINDING SITE FOR RESIDUE EDO A 602 source : BC3 84) chain A residue 165 type sequence R description BINDING SITE FOR RESIDUE EDO A 603 source : BC4 85) chain A residue 167 type sequence H description BINDING SITE FOR RESIDUE EDO A 603 source : BC4 86) chain A residue 370 type sequence S description BINDING SITE FOR RESIDUE EDO A 603 source : BC4 87) chain A residue 372 type sequence P description BINDING SITE FOR RESIDUE EDO A 603 source : BC4 88) chain A residue 266 type sequence D description BINDING SITE FOR RESIDUE EDO A 604 source : BC5 89) chain A residue 269 type sequence D description BINDING SITE FOR RESIDUE EDO A 604 source : BC5 90) chain B residue 260 type sequence K description BINDING SITE FOR RESIDUE EDO A 604 source : BC5 91) chain B residue 314 type sequence W description BINDING SITE FOR RESIDUE EDO A 604 source : BC5 92) chain B residue 215 type sequence F description BINDING SITE FOR RESIDUE EDO B 605 source : BC6 93) chain B residue 225 type sequence L description BINDING SITE FOR RESIDUE EDO B 605 source : BC6 94) chain B residue 362 type sequence Y description BINDING SITE FOR RESIDUE EDO B 605 source : BC6 95) chain B residue 226 type sequence V description BINDING SITE FOR RESIDUE EDO B 606 source : BC7 96) chain B residue 227 type sequence E description BINDING SITE FOR RESIDUE EDO B 606 source : BC7 97) chain B residue 362 type sequence Y description BINDING SITE FOR RESIDUE EDO B 606 source : BC7 98) chain A residue 213 type sequence K description BINDING SITE FOR RESIDUE EDO B 607 source : BC8 99) chain B residue 185 type sequence Q description BINDING SITE FOR RESIDUE EDO B 607 source : BC8 100) chain B residue 196 type sequence Y description BINDING SITE FOR RESIDUE EDO B 607 source : BC8 101) chain A residue 215 type sequence F description BINDING SITE FOR RESIDUE EDO A 608 source : BC9 102) chain A residue 225 type sequence L description BINDING SITE FOR RESIDUE EDO A 608 source : BC9 103) chain A residue 227 type sequence E description BINDING SITE FOR RESIDUE EDO A 608 source : BC9 104) chain A residue 362 type sequence Y description BINDING SITE FOR RESIDUE EDO A 608 source : BC9 105) chain A residue 250-260 type prosite sequence GHAHAGMGKIK description SYNAPSIN_2 Synapsins signature 2. GHAHAGMGKIK source prosite : PS00416

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