eF-site ID 2oy0-B PDB Code 2oy0 Chain B click to enlarge Title Crystal structure of the West Nile virus methyltransferase Classification VIRAL PROTEIN Compound Methyltransferase Source null (Q9Q6P4_WNV) Sequence B:  RTLGEVWKERLNQMTKEEFTRYRKEAIIEVDRSAAKHARK EGNVTGGHPVSRGTAKLRWLVERRFLEPVGKVIDLGCGRG GWCYYMATQKRVQEVRGYTKGGPGHEEPQLVQSYGWNIVT MKSGVDVFYRPSECCDTLLCDIGESSSSAEVEEHRTIRVL EMVEDWLHRGPREFCVKVLCPYMPKVIEKMELLQRRYGGG LVRNPLSRNSTHEMYWVSRASGNVVHSVNMTSQVLLGRME KRTWKGPQYEEDVNLGSGTRAV Description Functional site 1) chain B residue 200 type sequence R description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 2) chain B residue 56 type sequence S description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 3) chain B residue 58 type sequence G description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 4) chain B residue 81 type sequence G description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 5) chain B residue 82 type sequence C description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 6) chain B residue 83 type sequence G description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 7) chain B residue 86 type sequence G description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 8) chain B residue 87 type sequence W description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 9) chain B residue 104 type sequence T description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 10) chain B residue 105 type sequence K description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 11) chain B residue 110 type sequence H description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 12) chain B residue 111 type sequence E description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 13) chain B residue 131 type sequence D description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 14) chain B residue 132 type sequence V description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 15) chain B residue 133 type sequence F description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 16) chain B residue 146 type sequence D description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 17) chain B residue 147 type sequence I description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 18) chain B residue 56 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P03314 source Swiss-Prot : SWS_FT_FI11 19) chain B residue 61 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 20) chain B residue 182 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 21) chain B residue 218 type SITE sequence E description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 22) chain B residue 146 type SITE sequence D description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI10 23) chain B residue 61 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 146 type ACT_SITE sequence D description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 182 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 218 type ACT_SITE sequence E description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 56 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 86 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 29) chain B residue 87 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 131 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 31) chain B residue 132 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 32) chain B residue 104 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 33) chain B residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 34) chain B residue 147 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 35) chain B residue 220 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 36) chain B residue 111 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI5 37) chain B residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI5 38) chain B residue 13 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 39) chain B residue 17 type SITE sequence N description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 40) chain B residue 28 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 41) chain B residue 150 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 42) chain B residue 213 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 43) chain B residue 215 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 44) chain B residue 16 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 45) chain B residue 19 type SITE sequence M description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 46) chain B residue 24 type SITE sequence F description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI8

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