eF-site ID 2oy0-AB PDB Code 2oy0 Chain A, B click to enlarge Title Crystal structure of the West Nile virus methyltransferase Classification VIRAL PROTEIN Compound Methyltransferase Source West Nile virus (WNV) (Q9Q6P4_WNV) Sequence A:  RTLGEVWKERLNQMTKEEFTRYRKEAIIEVDRSAAKHARK EGNVTGGHPVSRGTAKLRWLVERRFLEPVGKVIDLGCGRG GWCYYMATQKRVQEVRGYTKGGPGHEEPQLVQSYGWNIVT MKSGVDVFYRPSECCDTLLCDIGESSSSAEVEEHRTIRVL EMVEDWLHRGPREFCVKVLCPYMPKVIEKMELLQRRYGGG LVRNPLSRNSTHEMYWVSRASGNVVHSVNMTSQVLLGRME KRTWKGPQYEEDVNLGSGTRAV B:  RTLGEVWKERLNQMTKEEFTRYRKEAIIEVDRSAAKHARK EGNVTGGHPVSRGTAKLRWLVERRFLEPVGKVIDLGCGRG GWCYYMATQKRVQEVRGYTKGGPGHEEPQLVQSYGWNIVT MKSGVDVFYRPSECCDTLLCDIGESSSSAEVEEHRTIRVL EMVEDWLHRGPREFCVKVLCPYMPKVIEKMELLQRRYGGG LVRNPLSRNSTHEMYWVSRASGNVVHSVNMTSQVLLGRME KRTWKGPQYEEDVNLGSGTRAV Description Functional site 1) chain A residue 56 type sequence S description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 2) chain A residue 58 type sequence G description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 3) chain A residue 81 type sequence G description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 4) chain A residue 82 type sequence C description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 5) chain A residue 83 type sequence G description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 6) chain A residue 84 type sequence R description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 7) chain A residue 85 type sequence G description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 8) chain A residue 86 type sequence G description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 9) chain A residue 87 type sequence W description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 10) chain A residue 104 type sequence T description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 11) chain A residue 105 type sequence K description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 12) chain A residue 110 type sequence H description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 13) chain A residue 111 type sequence E description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 14) chain A residue 131 type sequence D description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 15) chain A residue 132 type sequence V description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 16) chain A residue 133 type sequence F description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 17) chain A residue 146 type sequence D description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 18) chain A residue 149 type sequence E description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 19) chain B residue 200 type sequence R description BINDING SITE FOR RESIDUE SAH A 301 source : AC1 20) chain B residue 56 type sequence S description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 21) chain B residue 58 type sequence G description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 22) chain B residue 81 type sequence G description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 23) chain B residue 82 type sequence C description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 24) chain B residue 83 type sequence G description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 25) chain B residue 86 type sequence G description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 26) chain B residue 87 type sequence W description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 27) chain B residue 104 type sequence T description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 28) chain B residue 105 type sequence K description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 29) chain B residue 110 type sequence H description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 30) chain B residue 111 type sequence E description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 31) chain B residue 131 type sequence D description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 32) chain B residue 132 type sequence V description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 33) chain B residue 133 type sequence F description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 34) chain B residue 146 type sequence D description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 35) chain B residue 147 type sequence I description BINDING SITE FOR RESIDUE SAH B 302 source : AC2 36) chain A residue 56 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P03314 source Swiss-Prot : SWS_FT_FI11 37) chain B residue 56 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P03314 source Swiss-Prot : SWS_FT_FI11 38) chain A residue 61 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 146 type ACT_SITE sequence D description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 182 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 218 type ACT_SITE sequence E description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 61 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 43) chain B residue 146 type ACT_SITE sequence D description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 44) chain B residue 182 type ACT_SITE sequence K description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 45) chain B residue 218 type ACT_SITE sequence E description For 2'-O-MTase activity => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 56 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI2 47) chain B residue 56 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI2 48) chain A residue 86 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 49) chain A residue 87 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 50) chain A residue 131 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 51) chain A residue 132 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 52) chain B residue 86 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 53) chain B residue 87 type BINDING sequence W description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 54) chain B residue 131 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 55) chain B residue 132 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0007744|PDB:2OY0 source Swiss-Prot : SWS_FT_FI3 56) chain A residue 104 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 57) chain A residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 58) chain A residue 147 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 59) chain A residue 220 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 60) chain B residue 104 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 61) chain B residue 105 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 62) chain B residue 147 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 63) chain B residue 220 type BINDING sequence Y description BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI4 64) chain A residue 111 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI5 65) chain A residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI5 66) chain B residue 111 type BINDING sequence E description BINDING => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI5 67) chain B residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI5 68) chain A residue 13 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 69) chain B residue 150 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 70) chain B residue 213 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 71) chain B residue 215 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 72) chain A residue 17 type SITE sequence N description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 73) chain A residue 28 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 74) chain A residue 150 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 75) chain A residue 213 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 76) chain A residue 215 type SITE sequence S description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 77) chain B residue 13 type SITE sequence K description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 78) chain B residue 17 type SITE sequence N description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 79) chain B residue 28 type SITE sequence R description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI6 80) chain A residue 16 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 81) chain A residue 19 type SITE sequence M description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 82) chain B residue 16 type SITE sequence L description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 83) chain B residue 19 type SITE sequence M description mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI7 84) chain A residue 24 type SITE sequence F description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI8 85) chain B residue 24 type SITE sequence F description mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924, ECO:0000269|PubMed:17267492 source Swiss-Prot : SWS_FT_FI8 86) chain A residue 61 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 87) chain A residue 182 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 88) chain A residue 218 type SITE sequence E description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 89) chain B residue 61 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 90) chain B residue 182 type SITE sequence K description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 91) chain B residue 218 type SITE sequence E description Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI9 92) chain A residue 146 type SITE sequence D description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI10 93) chain B residue 146 type SITE sequence D description Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 source Swiss-Prot : SWS_FT_FI10

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