eF-site ID 2oud-A
PDB Code 2oud
Chain A

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Title Crystal structure of the catalytic domain of human MKP5
Classification HYDROLASE
Compound Dual specificity protein phosphatase 10
Source Homo sapiens (Human) (DUS10_HUMAN)
Sequence A:  PDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINV
TTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFI
EEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDA
YKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPK
LMGVETVVKEAAALEHH
Description


Functional site

1) chain A
residue 406-416
type prosite
sequence IHCQAGVSRSA
description TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCqaGvsRSA
source prosite : PS00383

2) chain A
residue 408
type ACT_SITE
sequence C
description Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000305|PubMed:16806267, ECO:0000305|PubMed:17400920
source Swiss-Prot : SWS_FT_FI1


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