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Title
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The structure of the anti-c-myc antibody 9E10 Fab fragment/epitope peptide complex reveals a novel binding mode dominated by the heavy chain hypervariable loops |
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Classification
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IMMUNE SYSTEM |
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Compound
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Monoclonal anti-c-myc antibody 9E10 |
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Source
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ORGANISM_COMMON: house mouse; ORGANISM_SCIENTIFIC: Mus musculus; |
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Sequence
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H: |
EVHLVESGGDLVKPGGSLKLSCAASGFTFSHYGMSWVRQT
PDKRLEWVATIGSRGTYTHYPDSVKGRFTISRDNDKNALY
LQMNSLKSEDTAMYYCARRSEFYYYGNTYYYSAMDYWGQG
ASVTVSSAKTTPPSVYPLAPGSSMVTLGCLVKGYFPEPVT
VTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSE
TVTCNVAHPASSTKVDKKIVP
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| I: |
EVHLVESGGDLVKPGGSLKLSCAASGFTFSHYGMSWVRQT
PDKRLEWVATIGSRGTYTHYPDSVKGRFTISRDNDKNALY
LQMNSLKSEDTAMYYCARRSEFYYYGNTYYYSAMDYWGQG
ASVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYF
PEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSS
TWPSETVTCNVAHPASSTKVDKKIVPRD
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| L: |
DIVLTQSPASLAVSLGQRATISCRASESVDNYGFSFMNWF
QQKPGQPPKLLIYAISNRGSGVPARFSGSGSGTDFSLNIH
PVEEDDPAMYFCQQTKEVPWTFGGGTKLEIKRADAAPTVS
IFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQ
NGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEA
THKTSTSPIVKSFNRN
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| M: |
DIVLTQSPASLAVSLGQRATISCRASESVDNYGFSFMNWF
QQKPGQPPKLLIYAISNRGSGVPARFSGSGSGTDFSLNIH
PVEEDDPAMYFCQQTKEVPWTFGGGTKLEIKRADAAPTVS
IFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQ
NGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEA
THKTSTSPIVKSFNRNEC
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| P: |
EQKLISEEDLN
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Description
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