eF-site ID 2omh-ABCDEF PDB Code 2omh Chain A, B, C, D, E, F click to enlarge Title Structure of human insulin cocrystallized with ARG-12 peptide in presence of urea Classification HORMONE Compound Insulin A chain Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence A:  GIVEQCCTSICSLYQLENYCN B:  FVNQHLCGSHLVEALYLVCGERGFFYTP C:  GIVEQCCTSICSLYQLENYCN D:  FVNQHLCGSHLVEALYLVCGERGFFYTP E:  GIVEQCCTSICSLYQLENYCN F:  FVNQHLCGSHLVEALYLVCGERGFFYTP Description Functional site 1) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 201 source : AC1 2) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 201 source : AC1 3) chain F residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN B 201 source : AC1 4) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE CL B 301 source : AC2 5) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE CL B 301 source : AC2 6) chain F residue 10 type sequence H description BINDING SITE FOR RESIDUE CL B 301 source : AC2 7) chain A residue 18 type sequence N description BINDING SITE FOR RESIDUE NA A 401 source : AC3 8) chain A residue 20 type sequence C description BINDING SITE FOR RESIDUE NA A 401 source : AC3 9) chain B residue 5 type sequence H description BINDING SITE FOR RESIDUE RCO E 501 source : AC4 10) chain D residue 17 type sequence L description BINDING SITE FOR RESIDUE RCO E 501 source : AC4 11) chain E residue 6 type sequence C description BINDING SITE FOR RESIDUE RCO E 501 source : AC4 12) chain E residue 9 type sequence S description BINDING SITE FOR RESIDUE RCO E 501 source : AC4 13) chain E residue 10 type sequence I description BINDING SITE FOR RESIDUE RCO E 501 source : AC4 14) chain E residue 11 type sequence C description BINDING SITE FOR RESIDUE RCO E 501 source : AC4 15) chain F residue 11 type sequence L description BINDING SITE FOR RESIDUE RCO E 501 source : AC4 16) chain F residue 14 type sequence A description BINDING SITE FOR RESIDUE RCO E 501 source : AC4 17) chain A residue 6 type sequence C description BINDING SITE FOR RESIDUE RCO A 502 source : AC5 18) chain A residue 9 type sequence S description BINDING SITE FOR RESIDUE RCO A 502 source : AC5 19) chain A residue 10 type sequence I description BINDING SITE FOR RESIDUE RCO A 502 source : AC5 20) chain A residue 11 type sequence C description BINDING SITE FOR RESIDUE RCO A 502 source : AC5 21) chain B residue 11 type sequence L description BINDING SITE FOR RESIDUE RCO A 502 source : AC5 22) chain B residue 14 type sequence A description BINDING SITE FOR RESIDUE RCO A 502 source : AC5 23) chain B residue 17 type sequence L description BINDING SITE FOR RESIDUE RCO A 502 source : AC5 24) chain D residue 5 type sequence H description BINDING SITE FOR RESIDUE RCO A 502 source : AC5 25) chain C residue 6 type sequence C description BINDING SITE FOR RESIDUE RCO C 503 source : AC6 26) chain C residue 10 type sequence I description BINDING SITE FOR RESIDUE RCO C 503 source : AC6 27) chain C residue 11 type sequence C description BINDING SITE FOR RESIDUE RCO C 503 source : AC6 28) chain D residue 11 type sequence L description BINDING SITE FOR RESIDUE RCO C 503 source : AC6 29) chain D residue 14 type sequence A description BINDING SITE FOR RESIDUE RCO C 503 source : AC6 30) chain F residue 5 type sequence H description BINDING SITE FOR RESIDUE RCO C 503 source : AC6 31) chain F residue 17 type sequence L description BINDING SITE FOR RESIDUE RCO C 503 source : AC6 32) chain A residue 5 type sequence Q description BINDING SITE FOR RESIDUE URE A 601 source : AC7 33) chain A residue 9 type sequence S description BINDING SITE FOR RESIDUE URE A 601 source : AC7 34) chain A residue 10 type sequence I description BINDING SITE FOR RESIDUE URE A 601 source : AC7 35) chain A residue 11 type sequence C description BINDING SITE FOR RESIDUE URE A 601 source : AC7 36) chain A residue 15 type sequence Q description BINDING SITE FOR RESIDUE URE A 601 source : AC7 37) chain F residue 5 type sequence H description BINDING SITE FOR RESIDUE URE F 602 source : AC8 38) chain F residue 16 type sequence Y description BINDING SITE FOR RESIDUE URE F 602 source : AC8 39) chain F residue 17 type sequence L description BINDING SITE FOR RESIDUE URE F 602 source : AC8 40) chain F residue 20 type sequence G description BINDING SITE FOR RESIDUE URE F 602 source : AC8 41) chain C residue 5 type sequence Q description BINDING SITE FOR RESIDUE URE C 603 source : AC9 42) chain C residue 9 type sequence S description BINDING SITE FOR RESIDUE URE C 603 source : AC9 43) chain C residue 10 type sequence I description BINDING SITE FOR RESIDUE URE C 603 source : AC9 44) chain C residue 11 type sequence C description BINDING SITE FOR RESIDUE URE C 603 source : AC9 45) chain C residue 15 type sequence Q description BINDING SITE FOR RESIDUE URE C 603 source : AC9 46) chain B residue 1 type sequence F description BINDING SITE FOR RESIDUE URE E 604 source : BC1 47) chain E residue 5 type sequence Q description BINDING SITE FOR RESIDUE URE E 604 source : BC1 48) chain E residue 9 type sequence S description BINDING SITE FOR RESIDUE URE E 604 source : BC1 49) chain E residue 10 type sequence I description BINDING SITE FOR RESIDUE URE E 604 source : BC1 50) chain E residue 11 type sequence C description BINDING SITE FOR RESIDUE URE E 604 source : BC1 51) chain E residue 15 type sequence Q description BINDING SITE FOR RESIDUE URE E 604 source : BC1 52) chain C residue 9 type sequence S description BINDING SITE FOR RESIDUE ARF F 701 source : BC2 53) chain C residue 10 type sequence I description BINDING SITE FOR RESIDUE ARF F 701 source : BC2 54) chain F residue 1 type sequence F description BINDING SITE FOR RESIDUE ARF F 701 source : BC2 55) chain A residue 21 type sequence N description BINDING SITE FOR RESIDUE ARF D 702 source : BC3 56) chain D residue 1 type sequence F description BINDING SITE FOR RESIDUE ARF D 702 source : BC3 57) chain D residue 2 type sequence V description BINDING SITE FOR RESIDUE ARF D 702 source : BC3 58) chain D residue 3 type sequence N description BINDING SITE FOR RESIDUE ARF D 702 source : BC3 59) chain D residue 4 type sequence Q description BINDING SITE FOR RESIDUE ARF D 702 source : BC3 60) chain A residue 6-20 type prosite sequence CCTSICSLYQLENYC description INSULIN Insulin family signature. CCTSiCSlyqLenyC source prosite : PS00262

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