eF-site ID 2okk-A PDB Code 2okk Chain A click to enlarge Title The X-ray crystal structure of the 65kDa isoform of Glutamic Acid Decarboxylase (GAD65) Classification LYASE Compound Glutamate decarboxylase 2 Source Homo sapiens (Human) (DCE2_HUMAN) Sequence A:  NYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFD RSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTL KYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTY EIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISN MYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKK GAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGF VPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAW GGGLLMSRKHKWKLSGVERANSVTWNPHXMMGVPLQCSAL LVREEGLMQNCNQMHDLSYDTGDKALQCGRHVDVFKLWLM WRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFDGK PQHTNVCFWYIPPSLRTLEERMSRLSKVAPVIKARMMEYG TTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERL GQD Description Functional site 1) chain A residue 181 type sequence Q description BINDING SITE FOR RESIDUE ABU A 585 source : AC1 2) chain A residue 182 type sequence L description BINDING SITE FOR RESIDUE ABU A 585 source : AC1 3) chain A residue 183 type sequence S description BINDING SITE FOR RESIDUE ABU A 585 source : AC1 4) chain A residue 205 type sequence F description BINDING SITE FOR RESIDUE ABU A 585 source : AC1 5) chain A residue 339 type sequence T description BINDING SITE FOR RESIDUE ABU A 585 source : AC1 6) chain A residue 558 type sequence R description BINDING SITE FOR RESIDUE ABU A 585 source : AC1 7) chain A residue 181 type sequence Q description BINDING SITE FOR RESIDUE ABU A 586 source : AC2 8) chain A residue 182 type sequence L description BINDING SITE FOR RESIDUE ABU A 586 source : AC2 9) chain A residue 183 type sequence S description BINDING SITE FOR RESIDUE ABU A 586 source : AC2 10) chain A residue 203 type sequence N description BINDING SITE FOR RESIDUE ABU A 586 source : AC2 11) chain A residue 282 type sequence H description BINDING SITE FOR RESIDUE ABU A 586 source : AC2 12) chain A residue 396 type sequence X description BINDING SITE FOR RESIDUE ABU A 586 source : AC2 13) chain A residue 446 type sequence C description BINDING SITE FOR RESIDUE ABU A 586 source : AC2 14) chain A residue 279 type sequence E description BINDING SITE FOR RESIDUE GOL A 587 source : AC3 15) chain A residue 281 type sequence S description BINDING SITE FOR RESIDUE GOL A 587 source : AC3 16) chain A residue 282 type sequence H description BINDING SITE FOR RESIDUE GOL A 587 source : AC3 17) chain A residue 283 type sequence F description BINDING SITE FOR RESIDUE GOL A 587 source : AC3 18) chain A residue 286 type sequence K description BINDING SITE FOR RESIDUE GOL A 587 source : AC3 19) chain A residue 396 type MOD_RES sequence X description N6-(pyridoxal phosphate)lysine source Swiss-Prot : SWS_FT_FI3 20) chain A residue 181 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI1 21) chain A residue 558 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17384644 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 389-410 type prosite sequence SVTWNPHXMMGVPLQCSALLVR description DDC_GAD_HDC_YDC DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. SVtWnphKMMgVpLQCsaLLvR source prosite : PS00392

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