eF-site ID 2okj-AB PDB Code 2okj Chain A, B click to enlarge Title The X-ray crystal structure of the 67kDa isoform of Glutamic Acid Decarboxylase (GAD67) Classification LYASE Compound Glutamate decarboxylase 1 Source null (DCE1_HUMAN) Sequence A:  TDFSNLFARDLLPAKNGEEQTVQFLLEVVDILLNYVRKTF DRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDC RDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTN MFTYEIAPVFVLMEQITLKKMREIVGWSSKDGDGIFSPGG AISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHY SIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAK QKGYVPFYVNATAGTTVYGAFDPIQEIADICEKYNLWLHV DAAWGGGLLMSRKHRHKLNGIERANSVTWNPHXMMGVLLQ CSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKA IQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYA KIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRR EKLHKVAPKIKALMMESGTTMVGYQPQGDKANFFRMVISN PAATQSDIDFLIEEIERLGQD B:  TDFSNLFARDLLPAKNGEEQTVQFLLEVVDILLNYVRKTF DRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDC RDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTN MFTYEIAPVFVLMEQITLKKMREIVGWSSKDGDGIFSPGG AISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHY SIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAK QKGYVPFYVNATAGTTVYGAFDPIQEIADICEKYNLWLHV DAAWGGGLLMSRKHRHKLNGIERANSVTWNPHXMMGVLLQ CSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKA IQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYA KIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRR EKLHKVAPKIKALMMESGTTMVGYQPQGDKANFFRMVISN PAATQSDIDFLIEEIERLGQDLHH Description Functional site 1) chain A residue 190 type sequence Q description BINDING SITE FOR RESIDUE ABU A 1001 source : AC1 2) chain A residue 191 type sequence L description BINDING SITE FOR RESIDUE ABU A 1001 source : AC1 3) chain A residue 192 type sequence S description BINDING SITE FOR RESIDUE ABU A 1001 source : AC1 4) chain A residue 567 type sequence R description BINDING SITE FOR RESIDUE ABU A 1001 source : AC1 5) chain B residue 434 type sequence Y description BINDING SITE FOR RESIDUE ABU A 1001 source : AC1 6) chain A residue 435 type sequence L description BINDING SITE FOR RESIDUE ABU B 1002 source : AC2 7) chain B residue 189 type sequence N description BINDING SITE FOR RESIDUE ABU B 1002 source : AC2 8) chain B residue 190 type sequence Q description BINDING SITE FOR RESIDUE ABU B 1002 source : AC2 9) chain B residue 191 type sequence L description BINDING SITE FOR RESIDUE ABU B 1002 source : AC2 10) chain B residue 192 type sequence S description BINDING SITE FOR RESIDUE ABU B 1002 source : AC2 11) chain B residue 567 type sequence R description BINDING SITE FOR RESIDUE ABU B 1002 source : AC2 12) chain A residue 214 type sequence F description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 13) chain A residue 455 type sequence C description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 14) chain A residue 456 type sequence G description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 15) chain B residue 190 type sequence Q description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 16) chain B residue 191 type sequence L description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 17) chain B residue 192 type sequence S description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 18) chain B residue 251 type sequence G description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 19) chain B residue 252 type sequence G description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 20) chain B residue 253 type sequence A description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 21) chain B residue 291 type sequence H description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 22) chain B residue 346 type sequence G description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 23) chain B residue 348 type sequence T description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 24) chain B residue 373 type sequence D description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 25) chain B residue 375 type sequence A description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 26) chain B residue 402 type sequence N description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 27) chain B residue 404 type sequence H description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 28) chain B residue 405 type sequence X description BINDING SITE FOR RESIDUE PLZ B 2001 source : AC3 29) chain A residue 398-419 type prosite sequence SVTWNPHXMMGVLLQCSAILVK description DDC_GAD_HDC_YDC DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. SVtWnphKMMgVlLQCsaILvK source prosite : PS00392 30) chain A residue 190 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17384644, ECO:0007744|PDB:2OKJ source Swiss-Prot : SWS_FT_FI1 31) chain A residue 567 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17384644, ECO:0007744|PDB:2OKJ source Swiss-Prot : SWS_FT_FI1 32) chain B residue 190 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17384644, ECO:0007744|PDB:2OKJ source Swiss-Prot : SWS_FT_FI1 33) chain B residue 567 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17384644, ECO:0007744|PDB:2OKJ source Swiss-Prot : SWS_FT_FI1 34) chain A residue 405 type MOD_RES sequence X description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:17384644, ECO:0007744|PDB:2OKJ source Swiss-Prot : SWS_FT_FI2 35) chain B residue 405 type MOD_RES sequence X description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:17384644, ECO:0007744|PDB:2OKJ source Swiss-Prot : SWS_FT_FI2

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