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eF-site ID
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2ojv-A |
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PDB Code
|
2ojv |
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Chain
|
A |
|
click to enlarge
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Title
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Crystal structure of a ternary complex of goat lactoperoxidase with cyanide and iodide ions at 2.4 A resolution |
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Classification
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METAL BINDING PROTEIN, OXIDOREDUCTASE |
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Compound
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Lactoperoxidase |
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Source
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ORGANISM_COMMON: goat; ORGANISM_SCIENTIFIC: Capra hircus; |
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Sequence
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A: |
SWEVGCGAPVPLVTCDEQSPYRTITGDCNNRRSPALGAAN
RALARWLPAEYEDGLAVPFGWTQRKTRNGFRVPLAREVSN
KIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELG
SSEHSKVQCEEYCVQGDECFPIMFPKNDPKLKTQGKCMPF
FRAGFVCPTPPYQSLARDQINAVTSFLDASLVYGSEPSLA
SRLRNLSSPLGLMAVNQEAWDHGLAYPPFNNVKPSPCEFI
NTTAHVPCFQAGDSRASEQILLATVHTLLLREHNRLAREL
KRLNPHWDGEMLYQEARKILGAFIQIITFRDYLPIVLGSE
MQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSR
LDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLL
AKNSKLMNQNKMVTSELRNKLFQPTHKVHGFDLAAINLQR
CRDHGMPGYNSWRGFCGLSQPKTLKGLQAVLKNKVLAKKL
LDLYKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQ
QIRDGDRFWWENPGVFTEKQRDSLQKVSFSRLICDNTHIT
KVPLHAFQANNYPHDFVDCSAVDKLDLSPWASREN
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
109 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00298
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
A |
| residue |
365 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
3'-nitrotyrosine => ECO:0000250|UniProtKB:P11678
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
3)
|
chain |
A |
| residue |
198 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000269|PubMed:18191143
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
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4)
|
chain |
A |
| residue |
108 |
| type |
BINDING |
| sequence |
D
|
| description |
covalent => ECO:0000269|PubMed:18191143, ECO:0000269|PubMed:27398304, ECO:0000269|Ref.11, ECO:0000269|Ref.5, ECO:0000269|Ref.6, ECO:0000269|Ref.7, ECO:0007744|PDB:2E9E, ECO:0007744|PDB:2EFB, ECO:0007744|PDB:2EHA, ECO:0007744|PDB:2OJV, ECO:0007744|PDB:2R5L, ECO:0007744|PDB:3N8F, ECO:0007744|PDB:3NAK, ECO:0007744|PDB:3NIU, ECO:0007744|PDB:3QF1, ECO:0007744|PDB:3R55, ECO:0007744|PDB:3RKE, ECO:0007744|PDB:3SXV, ECO:0007744|PDB:4MSF, ECO:0007744|PDB:4OEK, ECO:0007744|PDB:4QJQ, ECO:0007744|PDB:5FF1, ECO:0007744|PDB:5HPW, ECO:0007744|PDB:6LF7, ECO:0007744|PDB:8ING
|
| source |
Swiss-Prot : SWS_FT_FI2
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|
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5)
|
chain |
A |
| residue |
258 |
| type |
BINDING |
| sequence |
E
|
| description |
covalent => ECO:0000269|PubMed:18191143, ECO:0000269|PubMed:27398304, ECO:0000269|Ref.11, ECO:0000269|Ref.5, ECO:0000269|Ref.6, ECO:0000269|Ref.7, ECO:0007744|PDB:2E9E, ECO:0007744|PDB:2EFB, ECO:0007744|PDB:2EHA, ECO:0007744|PDB:2OJV, ECO:0007744|PDB:2R5L, ECO:0007744|PDB:3N8F, ECO:0007744|PDB:3NAK, ECO:0007744|PDB:3NIU, ECO:0007744|PDB:3QF1, ECO:0007744|PDB:3R55, ECO:0007744|PDB:3RKE, ECO:0007744|PDB:3SXV, ECO:0007744|PDB:4MSF, ECO:0007744|PDB:4OEK, ECO:0007744|PDB:4QJQ, ECO:0007744|PDB:5FF1, ECO:0007744|PDB:5HPW, ECO:0007744|PDB:6LF7, ECO:0007744|PDB:8ING
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
A |
| residue |
110 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:18191143, ECO:0000269|PubMed:27398304, ECO:0000269|Ref.11, ECO:0000269|Ref.5, ECO:0000269|Ref.6, ECO:0000269|Ref.7, ECO:0007744|PDB:2E9E, ECO:0007744|PDB:2EFB, ECO:0007744|PDB:2EHA, ECO:0007744|PDB:2OJV, ECO:0007744|PDB:2R5L, ECO:0007744|PDB:3N8F, ECO:0007744|PDB:3NAK, ECO:0007744|PDB:3NIU, ECO:0007744|PDB:3QF1, ECO:0007744|PDB:3R55, ECO:0007744|PDB:3RKE, ECO:0007744|PDB:3SXV, ECO:0007744|PDB:4MSF, ECO:0007744|PDB:4OEK, ECO:0007744|PDB:4QJQ, ECO:0007744|PDB:5FF1, ECO:0007744|PDB:5HPW, ECO:0007744|PDB:6LF7, ECO:0007744|PDB:8ING
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
7)
|
chain |
A |
| residue |
184 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000269|PubMed:18191143, ECO:0000269|PubMed:27398304, ECO:0000269|Ref.11, ECO:0000269|Ref.5, ECO:0000269|Ref.6, ECO:0000269|Ref.7, ECO:0007744|PDB:2E9E, ECO:0007744|PDB:2EFB, ECO:0007744|PDB:2EHA, ECO:0007744|PDB:2OJV, ECO:0007744|PDB:2R5L, ECO:0007744|PDB:3N8F, ECO:0007744|PDB:3NAK, ECO:0007744|PDB:3NIU, ECO:0007744|PDB:3QF1, ECO:0007744|PDB:3R55, ECO:0007744|PDB:3RKE, ECO:0007744|PDB:3SXV, ECO:0007744|PDB:4MSF, ECO:0007744|PDB:4OEK, ECO:0007744|PDB:4QJQ, ECO:0007744|PDB:5FF1, ECO:0007744|PDB:5HPW, ECO:0007744|PDB:6LF7, ECO:0007744|PDB:8ING
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
8)
|
chain |
A |
| residue |
186 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000269|PubMed:18191143, ECO:0000269|PubMed:27398304, ECO:0000269|Ref.11, ECO:0000269|Ref.5, ECO:0000269|Ref.6, ECO:0000269|Ref.7, ECO:0007744|PDB:2E9E, ECO:0007744|PDB:2EFB, ECO:0007744|PDB:2EHA, ECO:0007744|PDB:2OJV, ECO:0007744|PDB:2R5L, ECO:0007744|PDB:3N8F, ECO:0007744|PDB:3NAK, ECO:0007744|PDB:3NIU, ECO:0007744|PDB:3QF1, ECO:0007744|PDB:3R55, ECO:0007744|PDB:3RKE, ECO:0007744|PDB:3SXV, ECO:0007744|PDB:4MSF, ECO:0007744|PDB:4OEK, ECO:0007744|PDB:4QJQ, ECO:0007744|PDB:5FF1, ECO:0007744|PDB:5HPW, ECO:0007744|PDB:6LF7, ECO:0007744|PDB:8ING
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
9)
|
chain |
A |
| residue |
188 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:18191143, ECO:0000269|PubMed:27398304, ECO:0000269|Ref.11, ECO:0000269|Ref.5, ECO:0000269|Ref.6, ECO:0000269|Ref.7, ECO:0007744|PDB:2E9E, ECO:0007744|PDB:2EFB, ECO:0007744|PDB:2EHA, ECO:0007744|PDB:2OJV, ECO:0007744|PDB:2R5L, ECO:0007744|PDB:3N8F, ECO:0007744|PDB:3NAK, ECO:0007744|PDB:3NIU, ECO:0007744|PDB:3QF1, ECO:0007744|PDB:3R55, ECO:0007744|PDB:3RKE, ECO:0007744|PDB:3SXV, ECO:0007744|PDB:4MSF, ECO:0007744|PDB:4OEK, ECO:0007744|PDB:4QJQ, ECO:0007744|PDB:5FF1, ECO:0007744|PDB:5HPW, ECO:0007744|PDB:6LF7, ECO:0007744|PDB:8ING
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
10)
|
chain |
A |
| residue |
190 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:18191143, ECO:0000269|PubMed:27398304, ECO:0000269|Ref.11, ECO:0000269|Ref.5, ECO:0000269|Ref.6, ECO:0000269|Ref.7, ECO:0007744|PDB:2E9E, ECO:0007744|PDB:2EFB, ECO:0007744|PDB:2EHA, ECO:0007744|PDB:2OJV, ECO:0007744|PDB:2R5L, ECO:0007744|PDB:3N8F, ECO:0007744|PDB:3NAK, ECO:0007744|PDB:3NIU, ECO:0007744|PDB:3QF1, ECO:0007744|PDB:3R55, ECO:0007744|PDB:3RKE, ECO:0007744|PDB:3SXV, ECO:0007744|PDB:4MSF, ECO:0007744|PDB:4OEK, ECO:0007744|PDB:4QJQ, ECO:0007744|PDB:5FF1, ECO:0007744|PDB:5HPW, ECO:0007744|PDB:6LF7, ECO:0007744|PDB:8ING
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
11)
|
chain |
A |
| residue |
351 |
| type |
BINDING |
| sequence |
H
|
| description |
axial binding residue => ECO:0000269|PubMed:18191143, ECO:0000269|PubMed:27398304, ECO:0000269|Ref.11, ECO:0000269|Ref.5, ECO:0000269|Ref.6, ECO:0000269|Ref.7, ECO:0007744|PDB:2E9E, ECO:0007744|PDB:2EFB, ECO:0007744|PDB:2EHA, ECO:0007744|PDB:2OJV, ECO:0007744|PDB:2R5L, ECO:0007744|PDB:3N8F, ECO:0007744|PDB:3NAK, ECO:0007744|PDB:3NIU, ECO:0007744|PDB:3QF1, ECO:0007744|PDB:3R55, ECO:0007744|PDB:3RKE, ECO:0007744|PDB:3SXV, ECO:0007744|PDB:4MSF, ECO:0007744|PDB:4OEK, ECO:0007744|PDB:4QJQ, ECO:0007744|PDB:5FF1, ECO:0007744|PDB:5HPW, ECO:0007744|PDB:6LF7, ECO:0007744|PDB:8ING
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
12)
|
chain |
A |
| residue |
95 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (hybrid) asparagine; alternate => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:18191143, ECO:0000269|PubMed:27398304, ECO:0000269|PubMed:30296068, ECO:0000269|Ref.11, ECO:0000269|Ref.5, ECO:0000269|Ref.6, ECO:0000269|Ref.7, ECO:0007744|PDB:2E9E, ECO:0007744|PDB:2EFB, ECO:0007744|PDB:2EHA, ECO:0007744|PDB:2OJV, ECO:0007744|PDB:2R5L, ECO:0007744|PDB:3N8F, ECO:0007744|PDB:3NAK, ECO:0007744|PDB:3NIU, ECO:0007744|PDB:3R55, ECO:0007744|PDB:3RKE, ECO:0007744|PDB:3SXV, ECO:0007744|PDB:4MSF, ECO:0007744|PDB:4OEK, ECO:0007744|PDB:4QJQ, ECO:0007744|PDB:5FF1, ECO:0007744|PDB:5HPW, ECO:0007744|PDB:6LF7, ECO:0007744|PDB:8ING
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
13)
|
chain |
A |
| residue |
205 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:18191143, ECO:0000269|PubMed:27398304, ECO:0000269|PubMed:30296068, ECO:0000269|Ref.11, ECO:0000269|Ref.5, ECO:0000269|Ref.6, ECO:0000269|Ref.7, ECO:0007744|PDB:2E9E, ECO:0007744|PDB:2EFB, ECO:0007744|PDB:2EHA, ECO:0007744|PDB:2OJV, ECO:0007744|PDB:2R5L, ECO:0007744|PDB:3N8F, ECO:0007744|PDB:3NAK, ECO:0007744|PDB:3NIU, ECO:0007744|PDB:3QF1, ECO:0007744|PDB:3R55, ECO:0007744|PDB:3RKE, ECO:0007744|PDB:3SXV, ECO:0007744|PDB:4MSF, ECO:0007744|PDB:4OEK, ECO:0007744|PDB:4QJQ, ECO:0007744|PDB:5FF1, ECO:0007744|PDB:5HPW, ECO:0007744|PDB:6LF7, ECO:0007744|PDB:8ING
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
14)
|
chain |
A |
| residue |
241 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:18191143, ECO:0000269|PubMed:27398304, ECO:0000269|Ref.11, ECO:0000269|Ref.5, ECO:0000269|Ref.6, ECO:0000269|Ref.7, ECO:0007744|PDB:2E9E, ECO:0007744|PDB:2EFB, ECO:0007744|PDB:2EHA, ECO:0007744|PDB:2OJV, ECO:0007744|PDB:2R5L, ECO:0007744|PDB:3N8F, ECO:0007744|PDB:3NAK, ECO:0007744|PDB:3NIU, ECO:0007744|PDB:3QF1, ECO:0007744|PDB:3R55, ECO:0007744|PDB:3RKE, ECO:0007744|PDB:3SXV, ECO:0007744|PDB:4MSF, ECO:0007744|PDB:4OEK, ECO:0007744|PDB:4QJQ, ECO:0007744|PDB:5FF1, ECO:0007744|PDB:5HPW, ECO:0007744|PDB:6LF7, ECO:0007744|PDB:8ING
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
15)
|
chain |
A |
| residue |
332 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (hybrid) asparagine; alternate => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:18191143, ECO:0000269|PubMed:27398304, ECO:0000269|PubMed:30296068, ECO:0000269|Ref.11, ECO:0000269|Ref.5, ECO:0000269|Ref.6, ECO:0000269|Ref.7, ECO:0007744|PDB:2E9E, ECO:0007744|PDB:2EFB, ECO:0007744|PDB:2EHA, ECO:0007744|PDB:2OJV, ECO:0007744|PDB:2R5L, ECO:0007744|PDB:3N8F, ECO:0007744|PDB:3NAK, ECO:0007744|PDB:3NIU, ECO:0007744|PDB:3QF1, ECO:0007744|PDB:3R55, ECO:0007744|PDB:3RKE, ECO:0007744|PDB:3SXV, ECO:0007744|PDB:4MSF, ECO:0007744|PDB:4OEK, ECO:0007744|PDB:4QJQ, ECO:0007744|PDB:5FF1, ECO:0007744|PDB:5HPW, ECO:0007744|PDB:6LF7, ECO:0007744|PDB:8ING
|
| source |
Swiss-Prot : SWS_FT_FI11
|
|
|
16)
|
chain |
A |
| residue |
255 |
| type |
SITE |
| sequence |
R
|
| description |
Transition state stabilizer => ECO:0000255|PROSITE-ProRule:PRU00298
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|