eF-site ID 2oje-ABCDEFGH PDB Code 2oje Chain A, B, C, D, E, F, G, H click to enlarge Title Mycoplasma arthritidis-derived mitogen complexed with class II MHC molecule HLA-DR1/HA complex in the presence of EDTA Classification IMMUNE SYSTEM Compound HLA class II histocompatibility antigen, DR alpha chain precursor Source Homo sapiens (Human) (2OJE) Sequence A:  KEEHVIIQAEFYLNPDQSGEFXFDFDGDEIFHVDXAKKET VWRLEEFGRFASFEAQGALANIAVDKANLEIXTKRSNYTP ITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTW LRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVY DCRVEHWGLDEPLLKHWEFD B:  GDTRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRF DSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCR HNYGVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVS GFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVM LETVPRSGEVYTCQVEHPSVTSPLTVEWRA C:  PKYVKQNTLKLAT D:  SMKLRVENPKKAQKHFVQNLNNVVFTNKELEDIYNLSNKE ETKEVLKLFKLKVNQFYRHAFGIVNDYNGLLEYKEIFNMM FLKLSVVFDTQRKEANNVEQIKRNIAILDEIMAKADNDLS YFISQNKNFQELWDKAVKLTKEMKIKLKGQKLDLRDGEVA INKVRELFGSDKNVKELWWFRSLLVKGVYLIKRYYEGDIE LKTTSDFAKAVFED E:  KEEHVIIQAEFYLNPDQSGEFXFDFDGDEIFHVDXAKKET VWRLEEFGRFASFEAQGALANIAVDKANLEIXTKRSNYTP ITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTW LRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVY DCRVEHWGLDEPLLKHWEFD F:  GDTRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRF DSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCR HNYGVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVS GFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVM LETVPRSGEVYTCQVEHPSVTSPLTVEWRA G:  PKYVKQNTLKLAT H:  SMKLRVENPKKAQKHFVQNLNNVVFTNKELEDIYNLSNKE ETKEVLKLFKLKVNQFYRHAFGIVNDYNGLLEYKEIFNMM FLKLSVVFDTQRKEANNVEQIKRNIAILDEIMAKADNDLS YFISQNKNFQELWDKAVKLTKEMKIKLKGQKLDLRDGEVA INKVRELFGSDKNVKELWWFRSLLVKGVYLIKRYYEGDIE LKTTSDFAKAVFED Description Functional site 1) chain A residue 61 type sequence A description BINDING SITE FOR RESIDUE PO4 D 214 source : AC1 2) chain C residue 310 type sequence K description BINDING SITE FOR RESIDUE PO4 D 214 source : AC1 3) chain D residue 11 type sequence A description BINDING SITE FOR RESIDUE PO4 D 214 source : AC1 4) chain D residue 12 type sequence Q description BINDING SITE FOR RESIDUE PO4 D 214 source : AC1 5) chain D residue 14 type sequence H description BINDING SITE FOR RESIDUE PO4 D 214 source : AC1 6) chain D residue 113 type sequence K description BINDING SITE FOR RESIDUE PO4 D 214 source : AC1 7) chain D residue 117 type sequence D description BINDING SITE FOR RESIDUE PO4 D 214 source : AC1 8) chain A residue 58 type sequence G description BINDING SITE FOR RESIDUE PO4 C 202 source : AC2 9) chain C residue 307 type sequence K description BINDING SITE FOR RESIDUE PO4 C 202 source : AC2 10) chain C residue 310 type sequence K description BINDING SITE FOR RESIDUE PO4 C 202 source : AC2 11) chain D residue 10 type sequence K description BINDING SITE FOR RESIDUE PO4 C 202 source : AC2 12) chain D residue 113 type sequence K description BINDING SITE FOR RESIDUE PO4 C 202 source : AC2 13) chain G residue 310 type sequence K description BINDING SITE FOR RESIDUE PO4 H 214 source : AC3 14) chain H residue 11 type sequence A description BINDING SITE FOR RESIDUE PO4 H 214 source : AC3 15) chain H residue 12 type sequence Q description BINDING SITE FOR RESIDUE PO4 H 214 source : AC3 16) chain H residue 14 type sequence H description BINDING SITE FOR RESIDUE PO4 H 214 source : AC3 17) chain H residue 113 type sequence K description BINDING SITE FOR RESIDUE PO4 H 214 source : AC3 18) chain H residue 117 type sequence D description BINDING SITE FOR RESIDUE PO4 H 214 source : AC3 19) chain E residue 55 type sequence E description BINDING SITE FOR RESIDUE PO4 E 204 source : AC4 20) chain E residue 58 type sequence G description BINDING SITE FOR RESIDUE PO4 E 204 source : AC4 21) chain G residue 310 type sequence K description BINDING SITE FOR RESIDUE PO4 E 204 source : AC4 22) chain B residue 19 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431 source Swiss-Prot : SWS_FT_FI3 23) chain F residue 19 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 53 type SITE sequence S description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI4 25) chain E residue 53 type SITE sequence S description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI4 26) chain B residue 57 type BINDING sequence D description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 61 type BINDING sequence W description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 81 type BINDING sequence H description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 82 type BINDING sequence N description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI1 30) chain F residue 57 type BINDING sequence D description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI1 31) chain F residue 61 type BINDING sequence W description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI1 32) chain F residue 81 type BINDING sequence H description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI1 33) chain F residue 82 type BINDING sequence N description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 93 type BINDING sequence R description BINDING => ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI2 35) chain F residue 93 type BINDING sequence R description BINDING => ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI2 36) chain E residue 49 type BINDING sequence G description BINDING => ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI2 37) chain E residue 52 type BINDING sequence A description BINDING => ECO:0000269|PubMed:8145819 source Swiss-Prot : SWS_FT_FI2 38) chain A residue 55 type SITE sequence E description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI5 39) chain E residue 55 type SITE sequence E description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI5 40) chain A residue 62 type SITE sequence N description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI6 41) chain E residue 62 type SITE sequence N description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI6 42) chain A residue 69 type SITE sequence N description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI7 43) chain E residue 69 type SITE sequence N description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI7 44) chain A residue 76 type SITE sequence R description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI8 45) chain E residue 76 type SITE sequence R description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI8 46) chain A residue 78 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 47) chain A residue 118 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 48) chain E residue 78 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 49) chain E residue 118 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 50) chain D residue 83-89 type prosite sequence LSVVFDT description LECTIN_LEGUME_BETA Legume lectins beta-chain signature. LSVVFDT source prosite : PS00307 51) chain A residue 161-167 type prosite sequence YDCRVEH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH source prosite : PS00290 52) chain B residue 171-177 type prosite sequence YTCQVEH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH source prosite : PS00290

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