eF-site ID 2ode-C PDB Code 2ode Chain C click to enlarge Title Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3 Classification SIGNALING PROTEIN Compound Guanine nucleotide-binding protein G(k) subunit alpha Source Homo sapiens (Human) (RGS8_HUMAN) Sequence C:  AKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYK VVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVL AGSAEEGVMTPELAGVIKRLWRDGGVQACFSRSREYQLND SASYYLNDLDRISQSNYIPTQQDVLRTRVKTTGIVETHFT FKDLYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDY DLVLAEDEEMNRMHESMKLFDSICNNKWFTETSIILFLNK KDLFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDL NRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNN Description Functional site 1) chain C residue 42 type sequence G description BINDING SITE FOR RESIDUE ALF C 2002 source : AC2 2) chain C residue 43 type sequence E description BINDING SITE FOR RESIDUE ALF C 2002 source : AC2 3) chain C residue 46 type sequence K description BINDING SITE FOR RESIDUE ALF C 2002 source : AC2 4) chain C residue 178 type sequence R description BINDING SITE FOR RESIDUE ALF C 2002 source : AC2 5) chain C residue 180 type sequence K description BINDING SITE FOR RESIDUE ALF C 2002 source : AC2 6) chain C residue 181 type sequence T description BINDING SITE FOR RESIDUE ALF C 2002 source : AC2 7) chain C residue 201 type sequence V description BINDING SITE FOR RESIDUE ALF C 2002 source : AC2 8) chain C residue 203 type sequence G description BINDING SITE FOR RESIDUE ALF C 2002 source : AC2 9) chain C residue 204 type sequence Q description BINDING SITE FOR RESIDUE ALF C 2002 source : AC2 10) chain C residue 47 type sequence S description BINDING SITE FOR RESIDUE MG C 3002 source : AC4 11) chain C residue 181 type sequence T description BINDING SITE FOR RESIDUE MG C 3002 source : AC4 12) chain C residue 43 type sequence E description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 13) chain C residue 44 type sequence S description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 14) chain C residue 45 type sequence G description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 15) chain C residue 46 type sequence K description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 16) chain C residue 47 type sequence S description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 17) chain C residue 48 type sequence T description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 18) chain C residue 151 type sequence S description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 19) chain C residue 175 type sequence L description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 20) chain C residue 176 type sequence R description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 21) chain C residue 177 type sequence T description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 22) chain C residue 178 type sequence R description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 23) chain C residue 269 type sequence N description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 24) chain C residue 270 type sequence K description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 25) chain C residue 272 type sequence D description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 26) chain C residue 273 type sequence L description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 27) chain C residue 325 type sequence C description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 28) chain C residue 326 type sequence A description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 29) chain C residue 327 type sequence T description BINDING SITE FOR RESIDUE GDP C 1002 source : AC6 30) chain C residue 43 type BINDING sequence E description BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S source Swiss-Prot : SWS_FT_FI1 31) chain C residue 175 type BINDING sequence L description BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S source Swiss-Prot : SWS_FT_FI1 32) chain C residue 269 type BINDING sequence N description BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S source Swiss-Prot : SWS_FT_FI1 33) chain C residue 47 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19478087, ECO:0007744|PDB:2V4Z source Swiss-Prot : SWS_FT_FI2 34) chain C residue 181 type BINDING sequence T description BINDING => ECO:0000269|PubMed:19478087, ECO:0007744|PDB:2V4Z source Swiss-Prot : SWS_FT_FI2 35) chain C residue 150 type BINDING sequence D description BINDING => ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S source Swiss-Prot : SWS_FT_FI3 36) chain C residue 200 type BINDING sequence D description BINDING => ECO:0000305|PubMed:19478087, ECO:0007744|PDB:2V4Z source Swiss-Prot : SWS_FT_FI4 37) chain C residue 326 type BINDING sequence A description BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R source Swiss-Prot : SWS_FT_FI5 38) chain C residue 178 type MOD_RES sequence R description ADP-ribosylarginine; by cholera toxin => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 39) chain C residue 204 type MOD_RES sequence Q description Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704 source Swiss-Prot : SWS_FT_FI7

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