eF-site ID 2ode-A PDB Code 2ode Chain A click to enlarge Title Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3 Classification SIGNALING PROTEIN Compound Guanine nucleotide-binding protein G(k) subunit alpha Source Homo sapiens (Human) (RGS8_HUMAN) Sequence A:  EVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYKVV VYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAG SAEEGVMTPELAGVIKRLWRDGGVQACFSRSREYQLNDSA SYYLNDLDRISQSNYIPTQQDVLRTRVKTTGIVETHFTFK DLYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDL VLAEDEEMNRMHESMKLFDSICNNKWFTETSIILFLNKKD LFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNR RKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNL Description Functional site 1) chain A residue 42 type sequence G description BINDING SITE FOR RESIDUE ALF A 2001 source : AC1 2) chain A residue 43 type sequence E description BINDING SITE FOR RESIDUE ALF A 2001 source : AC1 3) chain A residue 46 type sequence K description BINDING SITE FOR RESIDUE ALF A 2001 source : AC1 4) chain A residue 178 type sequence R description BINDING SITE FOR RESIDUE ALF A 2001 source : AC1 5) chain A residue 180 type sequence K description BINDING SITE FOR RESIDUE ALF A 2001 source : AC1 6) chain A residue 181 type sequence T description BINDING SITE FOR RESIDUE ALF A 2001 source : AC1 7) chain A residue 203 type sequence G description BINDING SITE FOR RESIDUE ALF A 2001 source : AC1 8) chain A residue 204 type sequence Q description BINDING SITE FOR RESIDUE ALF A 2001 source : AC1 9) chain A residue 47 type sequence S description BINDING SITE FOR RESIDUE MG A 3001 source : AC3 10) chain A residue 181 type sequence T description BINDING SITE FOR RESIDUE MG A 3001 source : AC3 11) chain A residue 43 type sequence E description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 12) chain A residue 44 type sequence S description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 13) chain A residue 45 type sequence G description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 14) chain A residue 46 type sequence K description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 15) chain A residue 47 type sequence S description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 16) chain A residue 48 type sequence T description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 17) chain A residue 151 type sequence S description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 18) chain A residue 175 type sequence L description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 19) chain A residue 176 type sequence R description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 20) chain A residue 177 type sequence T description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 21) chain A residue 178 type sequence R description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 22) chain A residue 269 type sequence N description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 23) chain A residue 270 type sequence K description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 24) chain A residue 272 type sequence D description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 25) chain A residue 273 type sequence L description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 26) chain A residue 325 type sequence C description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 27) chain A residue 326 type sequence A description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 28) chain A residue 327 type sequence T description BINDING SITE FOR RESIDUE GDP A 1001 source : AC5 29) chain A residue 43 type BINDING sequence E description BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S source Swiss-Prot : SWS_FT_FI1 30) chain A residue 175 type BINDING sequence L description BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S source Swiss-Prot : SWS_FT_FI1 31) chain A residue 269 type BINDING sequence N description BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S source Swiss-Prot : SWS_FT_FI1 32) chain A residue 47 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19478087, ECO:0007744|PDB:2V4Z source Swiss-Prot : SWS_FT_FI2 33) chain A residue 181 type BINDING sequence T description BINDING => ECO:0000269|PubMed:19478087, ECO:0007744|PDB:2V4Z source Swiss-Prot : SWS_FT_FI2 34) chain A residue 150 type BINDING sequence D description BINDING => ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S source Swiss-Prot : SWS_FT_FI3 35) chain A residue 200 type BINDING sequence D description BINDING => ECO:0000305|PubMed:19478087, ECO:0007744|PDB:2V4Z source Swiss-Prot : SWS_FT_FI4 36) chain A residue 178 type MOD_RES sequence R description ADP-ribosylarginine; by cholera toxin => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 37) chain A residue 204 type MOD_RES sequence Q description Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704 source Swiss-Prot : SWS_FT_FI7 38) chain A residue 326 type BINDING sequence A description BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R source Swiss-Prot : SWS_FT_FI5

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