|
|
eF-site ID
|
2obi-A |
|
PDB Code
|
2obi |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
Crystal structure of the Selenocysteine to Cysteine Mutant of human phospholipid hydroperoxide glutathione peroxidase (GPx4) |
|
Classification
|
OXIDOREDUCTASE |
|
Compound
|
Phospholipid hydroperoxide glutathione peroxidase (GPX4) |
|
Source
|
Homo sapiens (Human) (GPX4_HUMAN) |
|
|
Sequence
|
A: |
DDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQ
CGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGS
NEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPK
GKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKD
LPHYF
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
34-49 |
| type |
prosite |
| sequence |
GFVCIVTNVASQCGKT
|
| description |
GLUTATHIONE_PEROXID_1 Glutathione peroxidases active site. GFvCIVtNVaSqCGkT
|
| source |
prosite : PS00460
|
|
|
2)
|
chain |
A |
| residue |
71-78 |
| type |
prosite |
| sequence |
LAFPCNQF
|
| description |
GLUTATHIONE_PEROXID_2 Glutathione peroxidases signature 2. LAFPCNQF
|
| source |
prosite : PS00763
|
|
|
3)
|
chain |
A |
| residue |
46 |
| type |
ACT_SITE |
| sequence |
C
|
| description |
ACT_SITE => ECO:0000250|UniProtKB:O70325
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
A |
| residue |
13 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P36970
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|