eF-site ID 2o8j-ABCD PDB Code 2o8j Chain A, B, C, D click to enlarge Title Human euchromatic histone methyltransferase 2 Classification TRANSFERASE Compound Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Source Homo sapiens (Human) (EHMT2_HUMAN) Sequence A:  KIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCET STMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKD GRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVR LQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADV REDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVR VFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDYFT CQCGSEKCKHSAEA B:  ICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETST MNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGR LLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQ LYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVRE DDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIP VRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDI KSKYFTCQCGSEKCKHSAEAIALEQSRLARL C:  ICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETST MNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGR LLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQ LYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVRE DDSYLFDLEVYCIDARYYGNISRFINHLCDPNIIPVRVFM LHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYF TCQCGSEKCKHSAEAIALEQSR D:  ICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETST MNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGR LLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQ LYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVRE DDSYLFDLVYCIDARYYGNISRFINHLCDPNIIPVRVFML HQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWFTCQCGSE KCKHSAEA Description Functional site 1) chain A residue 974 type sequence C description BINDING SITE FOR RESIDUE ZN A 1501 source : AC1 2) chain A residue 987 type sequence C description BINDING SITE FOR RESIDUE ZN A 1501 source : AC1 3) chain A residue 1017 type sequence C description BINDING SITE FOR RESIDUE ZN A 1501 source : AC1 4) chain A residue 1021 type sequence C description BINDING SITE FOR RESIDUE ZN A 1501 source : AC1 5) chain A residue 980 type sequence C description BINDING SITE FOR RESIDUE ZN A 1502 source : AC2 6) chain A residue 1017 type sequence C description BINDING SITE FOR RESIDUE ZN A 1502 source : AC2 7) chain A residue 1023 type sequence C description BINDING SITE FOR RESIDUE ZN A 1502 source : AC2 8) chain A residue 1027 type sequence C description BINDING SITE FOR RESIDUE ZN A 1502 source : AC2 9) chain A residue 974 type sequence C description BINDING SITE FOR RESIDUE ZN A 1503 source : AC3 10) chain A residue 976 type sequence C description BINDING SITE FOR RESIDUE ZN A 1503 source : AC3 11) chain A residue 980 type sequence C description BINDING SITE FOR RESIDUE ZN A 1503 source : AC3 12) chain A residue 985 type sequence C description BINDING SITE FOR RESIDUE ZN A 1503 source : AC3 13) chain A residue 1115 type sequence C description BINDING SITE FOR RESIDUE ZN A 1504 source : AC4 14) chain A residue 1168 type sequence C description BINDING SITE FOR RESIDUE ZN A 1504 source : AC4 15) chain A residue 1170 type sequence C description BINDING SITE FOR RESIDUE ZN A 1504 source : AC4 16) chain A residue 1175 type sequence C description BINDING SITE FOR RESIDUE ZN A 1504 source : AC4 17) chain B residue 974 type sequence C description BINDING SITE FOR RESIDUE ZN B 1505 source : AC5 18) chain B residue 987 type sequence C description BINDING SITE FOR RESIDUE ZN B 1505 source : AC5 19) chain B residue 1017 type sequence C description BINDING SITE FOR RESIDUE ZN B 1505 source : AC5 20) chain B residue 1021 type sequence C description BINDING SITE FOR RESIDUE ZN B 1505 source : AC5 21) chain B residue 980 type sequence C description BINDING SITE FOR RESIDUE ZN B 1506 source : AC6 22) chain B residue 1017 type sequence C description BINDING SITE FOR RESIDUE ZN B 1506 source : AC6 23) chain B residue 1023 type sequence C description BINDING SITE FOR RESIDUE ZN B 1506 source : AC6 24) chain B residue 1027 type sequence C description BINDING SITE FOR RESIDUE ZN B 1506 source : AC6 25) chain B residue 974 type sequence C description BINDING SITE FOR RESIDUE ZN B 1507 source : AC7 26) chain B residue 976 type sequence C description BINDING SITE FOR RESIDUE ZN B 1507 source : AC7 27) chain B residue 980 type sequence C description BINDING SITE FOR RESIDUE ZN B 1507 source : AC7 28) chain B residue 985 type sequence C description BINDING SITE FOR RESIDUE ZN B 1507 source : AC7 29) chain B residue 1115 type sequence C description BINDING SITE FOR RESIDUE ZN B 1508 source : AC8 30) chain B residue 1168 type sequence C description BINDING SITE FOR RESIDUE ZN B 1508 source : AC8 31) chain B residue 1170 type sequence C description BINDING SITE FOR RESIDUE ZN B 1508 source : AC8 32) chain B residue 1175 type sequence C description BINDING SITE FOR RESIDUE ZN B 1508 source : AC8 33) chain C residue 974 type sequence C description BINDING SITE FOR RESIDUE ZN C 1509 source : AC9 34) chain C residue 987 type sequence C description BINDING SITE FOR RESIDUE ZN C 1509 source : AC9 35) chain C residue 1017 type sequence C description BINDING SITE FOR RESIDUE ZN C 1509 source : AC9 36) chain C residue 1021 type sequence C description BINDING SITE FOR RESIDUE ZN C 1509 source : AC9 37) chain C residue 980 type sequence C description BINDING SITE FOR RESIDUE ZN C 1510 source : BC1 38) chain C residue 1017 type sequence C description BINDING SITE FOR RESIDUE ZN C 1510 source : BC1 39) chain C residue 1023 type sequence C description BINDING SITE FOR RESIDUE ZN C 1510 source : BC1 40) chain C residue 1027 type sequence C description BINDING SITE FOR RESIDUE ZN C 1510 source : BC1 41) chain C residue 974 type sequence C description BINDING SITE FOR RESIDUE ZN C 1511 source : BC2 42) chain C residue 976 type sequence C description BINDING SITE FOR RESIDUE ZN C 1511 source : BC2 43) chain C residue 980 type sequence C description BINDING SITE FOR RESIDUE ZN C 1511 source : BC2 44) chain C residue 985 type sequence C description BINDING SITE FOR RESIDUE ZN C 1511 source : BC2 45) chain C residue 1115 type sequence C description BINDING SITE FOR RESIDUE ZN C 1512 source : BC3 46) chain C residue 1168 type sequence C description BINDING SITE FOR RESIDUE ZN C 1512 source : BC3 47) chain C residue 1170 type sequence C description BINDING SITE FOR RESIDUE ZN C 1512 source : BC3 48) chain C residue 1175 type sequence C description BINDING SITE FOR RESIDUE ZN C 1512 source : BC3 49) chain D residue 974 type sequence C description BINDING SITE FOR RESIDUE ZN D 1513 source : BC4 50) chain D residue 987 type sequence C description BINDING SITE FOR RESIDUE ZN D 1513 source : BC4 51) chain D residue 1017 type sequence C description BINDING SITE FOR RESIDUE ZN D 1513 source : BC4 52) chain D residue 1021 type sequence C description BINDING SITE FOR RESIDUE ZN D 1513 source : BC4 53) chain D residue 980 type sequence C description BINDING SITE FOR RESIDUE ZN D 1514 source : BC5 54) chain D residue 1017 type sequence C description BINDING SITE FOR RESIDUE ZN D 1514 source : BC5 55) chain D residue 1023 type sequence C description BINDING SITE FOR RESIDUE ZN D 1514 source : BC5 56) chain D residue 1027 type sequence C description BINDING SITE FOR RESIDUE ZN D 1514 source : BC5 57) chain D residue 974 type sequence C description BINDING SITE FOR RESIDUE ZN D 1515 source : BC6 58) chain D residue 976 type sequence C description BINDING SITE FOR RESIDUE ZN D 1515 source : BC6 59) chain D residue 980 type sequence C description BINDING SITE FOR RESIDUE ZN D 1515 source : BC6 60) chain D residue 985 type sequence C description BINDING SITE FOR RESIDUE ZN D 1515 source : BC6 61) chain D residue 1115 type sequence C description BINDING SITE FOR RESIDUE ZN D 1516 source : BC7 62) chain D residue 1168 type sequence C description BINDING SITE FOR RESIDUE ZN D 1516 source : BC7 63) chain D residue 1170 type sequence C description BINDING SITE FOR RESIDUE ZN D 1516 source : BC7 64) chain D residue 1175 type sequence C description BINDING SITE FOR RESIDUE ZN D 1516 source : BC7 65) chain A residue 1048 type sequence M description BINDING SITE FOR RESIDUE SAH A 1505 source : BC8 66) chain A residue 1050 type sequence W description BINDING SITE FOR RESIDUE SAH A 1505 source : BC8 67) chain A residue 1084 type sequence S description BINDING SITE FOR RESIDUE SAH A 1505 source : BC8 68) chain A residue 1085 type sequence Y description BINDING SITE FOR RESIDUE SAH A 1505 source : BC8 69) chain A residue 1109 type sequence R description BINDING SITE FOR RESIDUE SAH A 1505 source : BC8 70) chain A residue 1110 type sequence F description BINDING SITE FOR RESIDUE SAH A 1505 source : BC8 71) chain A residue 1112 type sequence N description BINDING SITE FOR RESIDUE SAH A 1505 source : BC8 72) chain A residue 1113 type sequence H description BINDING SITE FOR RESIDUE SAH A 1505 source : BC8 73) chain A residue 1154 type sequence Y description BINDING SITE FOR RESIDUE SAH A 1505 source : BC8 74) chain A residue 1166 type sequence F description BINDING SITE FOR RESIDUE SAH A 1505 source : BC8 75) chain A residue 1167 type sequence T description BINDING SITE FOR RESIDUE SAH A 1505 source : BC8 76) chain A residue 1168 type sequence C description BINDING SITE FOR RESIDUE SAH A 1505 source : BC8 77) chain A residue 1169 type sequence Q description BINDING SITE FOR RESIDUE SAH A 1505 source : BC8 78) chain B residue 1048 type sequence M description BINDING SITE FOR RESIDUE SAH B 1509 source : BC9 79) chain B residue 1050 type sequence W description BINDING SITE FOR RESIDUE SAH B 1509 source : BC9 80) chain B residue 1084 type sequence S description BINDING SITE FOR RESIDUE SAH B 1509 source : BC9 81) chain B residue 1085 type sequence Y description BINDING SITE FOR RESIDUE SAH B 1509 source : BC9 82) chain B residue 1109 type sequence R description BINDING SITE FOR RESIDUE SAH B 1509 source : BC9 83) chain B residue 1112 type sequence N description BINDING SITE FOR RESIDUE SAH B 1509 source : BC9 84) chain B residue 1113 type sequence H description BINDING SITE FOR RESIDUE SAH B 1509 source : BC9 85) chain B residue 1154 type sequence Y description BINDING SITE FOR RESIDUE SAH B 1509 source : BC9 86) chain B residue 1166 type sequence F description BINDING SITE FOR RESIDUE SAH B 1509 source : BC9 87) chain B residue 1168 type sequence C description BINDING SITE FOR RESIDUE SAH B 1509 source : BC9 88) chain B residue 1169 type sequence Q description BINDING SITE FOR RESIDUE SAH B 1509 source : BC9 89) chain C residue 1048 type sequence M description BINDING SITE FOR RESIDUE SAH C 1513 source : CC1 90) chain C residue 1050 type sequence W description BINDING SITE FOR RESIDUE SAH C 1513 source : CC1 91) chain C residue 1085 type sequence Y description BINDING SITE FOR RESIDUE SAH C 1513 source : CC1 92) chain C residue 1109 type sequence R description BINDING SITE FOR RESIDUE SAH C 1513 source : CC1 93) chain C residue 1110 type sequence F description BINDING SITE FOR RESIDUE SAH C 1513 source : CC1 94) chain C residue 1112 type sequence N description BINDING SITE FOR RESIDUE SAH C 1513 source : CC1 95) chain C residue 1113 type sequence H description BINDING SITE FOR RESIDUE SAH C 1513 source : CC1 96) chain C residue 1154 type sequence Y description BINDING SITE FOR RESIDUE SAH C 1513 source : CC1 97) chain C residue 1167 type sequence T description BINDING SITE FOR RESIDUE SAH C 1513 source : CC1 98) chain C residue 1168 type sequence C description BINDING SITE FOR RESIDUE SAH C 1513 source : CC1 99) chain C residue 1169 type sequence Q description BINDING SITE FOR RESIDUE SAH C 1513 source : CC1 100) chain D residue 1048 type sequence M description BINDING SITE FOR RESIDUE SAH D 1517 source : CC2 101) chain D residue 1050 type sequence W description BINDING SITE FOR RESIDUE SAH D 1517 source : CC2 102) chain D residue 1084 type sequence S description BINDING SITE FOR RESIDUE SAH D 1517 source : CC2 103) chain D residue 1085 type sequence Y description BINDING SITE FOR RESIDUE SAH D 1517 source : CC2 104) chain D residue 1109 type sequence R description BINDING SITE FOR RESIDUE SAH D 1517 source : CC2 105) chain D residue 1110 type sequence F description BINDING SITE FOR RESIDUE SAH D 1517 source : CC2 106) chain D residue 1112 type sequence N description BINDING SITE FOR RESIDUE SAH D 1517 source : CC2 107) chain D residue 1113 type sequence H description BINDING SITE FOR RESIDUE SAH D 1517 source : CC2 108) chain D residue 1154 type sequence Y description BINDING SITE FOR RESIDUE SAH D 1517 source : CC2 109) chain D residue 1166 type sequence F description BINDING SITE FOR RESIDUE SAH D 1517 source : CC2 110) chain D residue 1167 type sequence T description BINDING SITE FOR RESIDUE SAH D 1517 source : CC2 111) chain D residue 1168 type sequence C description BINDING SITE FOR RESIDUE SAH D 1517 source : CC2 112) chain D residue 1169 type sequence Q description BINDING SITE FOR RESIDUE SAH D 1517 source : CC2 113) chain A residue 974 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 114) chain A residue 1048 type BINDING sequence M description source Swiss-Prot : SWS_FT_FI1 115) chain A residue 1085 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 116) chain A residue 1112 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 117) chain A residue 1115 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 118) chain A residue 1168 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 119) chain A residue 1169 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI1 120) chain A residue 1170 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 121) chain A residue 1175 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 122) chain B residue 974 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 123) chain B residue 976 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 124) chain A residue 976 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 125) chain B residue 980 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 126) chain B residue 985 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 127) chain B residue 987 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 128) chain B residue 1017 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 129) chain B residue 1021 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 130) chain B residue 1023 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 131) chain B residue 1027 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 132) chain B residue 1048 type BINDING sequence M description source Swiss-Prot : SWS_FT_FI1 133) chain B residue 1085 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 134) chain B residue 1112 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 135) chain A residue 980 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 136) chain B residue 1115 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 137) chain B residue 1168 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 138) chain B residue 1169 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI1 139) chain B residue 1170 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 140) chain B residue 1175 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 141) chain C residue 974 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 142) chain C residue 976 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 143) chain C residue 980 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 144) chain C residue 985 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 145) chain C residue 987 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 146) chain A residue 985 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 147) chain C residue 1017 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 148) chain C residue 1021 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 149) chain C residue 1023 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 150) chain C residue 1027 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 151) chain C residue 1048 type BINDING sequence M description source Swiss-Prot : SWS_FT_FI1 152) chain C residue 1085 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 153) chain C residue 1112 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 154) chain C residue 1115 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 155) chain C residue 1168 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 156) chain C residue 1169 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI1 157) chain A residue 987 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 158) chain C residue 1170 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 159) chain C residue 1175 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 160) chain D residue 974 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 161) chain D residue 976 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 162) chain D residue 980 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 163) chain D residue 985 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 164) chain D residue 987 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 165) chain D residue 1017 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 166) chain D residue 1021 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 167) chain D residue 1023 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 168) chain A residue 1017 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 169) chain D residue 1027 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 170) chain D residue 1048 type BINDING sequence M description source Swiss-Prot : SWS_FT_FI1 171) chain D residue 1085 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 172) chain D residue 1112 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 173) chain D residue 1115 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 174) chain D residue 1168 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 175) chain D residue 1169 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI1 176) chain D residue 1170 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 177) chain D residue 1175 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 178) chain A residue 1021 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 179) chain A residue 1023 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 180) chain A residue 1027 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI1 181) chain A residue 1067 type SITE sequence Y description Histone H3K9me binding => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 182) chain B residue 1067 type SITE sequence Y description Histone H3K9me binding => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 183) chain C residue 1067 type SITE sequence Y description Histone H3K9me binding => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 184) chain D residue 1067 type SITE sequence Y description Histone H3K9me binding => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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