eF-site ID 2o5k-A PDB Code 2o5k Chain A click to enlarge Title Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor Classification TRANSFERASE Compound Glycogen synthase kinase-3 beta Source Homo sapiens (Human) (GSK3B_HUMAN) Sequence A:  SKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAK LCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP VIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTA VLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG TPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAI ALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGR DTPALFNFTTQELSSNPPLATILIPPHARI Description Functional site 1) chain A residue 62 type sequence I description BINDING SITE FOR RESIDUE HBM A 0 source : AC1 2) chain A residue 83 type sequence A description BINDING SITE FOR RESIDUE HBM A 0 source : AC1 3) chain A residue 133 type sequence D description BINDING SITE FOR RESIDUE HBM A 0 source : AC1 4) chain A residue 134 type sequence Y description BINDING SITE FOR RESIDUE HBM A 0 source : AC1 5) chain A residue 135 type sequence V description BINDING SITE FOR RESIDUE HBM A 0 source : AC1 6) chain A residue 136 type sequence P description BINDING SITE FOR RESIDUE HBM A 0 source : AC1 7) chain A residue 140 type sequence Y description BINDING SITE FOR RESIDUE HBM A 0 source : AC1 8) chain A residue 141 type sequence R description BINDING SITE FOR RESIDUE HBM A 0 source : AC1 9) chain A residue 185 type sequence Q description BINDING SITE FOR RESIDUE HBM A 0 source : AC1 10) chain A residue 186 type sequence N description BINDING SITE FOR RESIDUE HBM A 0 source : AC1 11) chain A residue 188 type sequence L description BINDING SITE FOR RESIDUE HBM A 0 source : AC1 12) chain A residue 200 type sequence D description BINDING SITE FOR RESIDUE HBM A 0 source : AC1 13) chain A residue 220 type sequence R description BINDING SITE FOR RESIDUE HBM A 0 source : AC1 14) chain A residue 181 type ACT_SITE sequence D description Proton acceptor source Swiss-Prot : SWS_FT_FI1 15) chain A residue 62 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 85 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006 source Swiss-Prot : SWS_FT_FI3 17) chain A residue 62-86 type prosite sequence IGNGSFGVVYQAKLCDSGELVAIKK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGSFGVVYqAklcdsgelv.........AIKK source prosite : PS00107 18) chain A residue 177-189 type prosite sequence ICHRDIKPQNLLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IcHrDIKpqNLLL source prosite : PS00108 19) chain A residue 216 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422 source Swiss-Prot : SWS_FT_FI4

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