eF-site ID 2o0l-AB
PDB Code 2o0l
Chain A, B

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Title Human spermidine synthase
Classification TRANSFERASE
Compound Spermidine synthase
Source Homo sapiens (Human) (SPEE_HUMAN)
Sequence A:  IREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFR
SKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPR
KVLIIGGGDGGVLREVVKHPSVESVVQCEIDEDVIQVSKK
FLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSS
ESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQS
LFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQPL
TQQQVAQMQLKYYNSDVHRAAFVLPEFARKALND
B:  AIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVF
RSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNP
RKVLIIGGGDGGVLREVVKHPSVESVVQCEIDEDVIQVSK
KFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDS
SDPMGPAESLFKESYYQLMKTALKEDGVLCCQGECQWLHL
DLIKEMRQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKN
PSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFA
RKALN
Description


Functional site

1) chain A
residue 49
type
sequence Q
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

2) chain A
residue 70
type
sequence Q
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

3) chain A
residue 79
type
sequence Y
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

4) chain A
residue 80
type
sequence Q
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

5) chain A
residue 101
type
sequence G
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

6) chain A
residue 103
type
sequence G
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

7) chain A
residue 104
type
sequence D
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

8) chain A
residue 123
type
sequence C
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

9) chain A
residue 124
type
sequence E
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

10) chain A
residue 125
type
sequence I
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

11) chain A
residue 126
type
sequence D
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

12) chain A
residue 129
type
sequence V
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

13) chain A
residue 154
type
sequence G
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

14) chain A
residue 155
type
sequence D
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

15) chain A
residue 156
type
sequence G
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

16) chain A
residue 173
type
sequence D
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

17) chain A
residue 241
type
sequence Y
description BINDING SITE FOR RESIDUE S4M A 501
source : AC1

18) chain B
residue 49
type
sequence Q
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

19) chain B
residue 65
type
sequence L
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

20) chain B
residue 70
type
sequence Q
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

21) chain B
residue 80
type
sequence Q
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

22) chain B
residue 101
type
sequence G
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

23) chain B
residue 103
type
sequence G
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

24) chain B
residue 104
type
sequence D
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

25) chain B
residue 123
type
sequence C
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

26) chain B
residue 124
type
sequence E
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

27) chain B
residue 125
type
sequence I
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

28) chain B
residue 126
type
sequence D
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

29) chain B
residue 129
type
sequence V
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

30) chain B
residue 154
type
sequence G
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

31) chain B
residue 155
type
sequence D
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

32) chain B
residue 156
type
sequence G
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

33) chain B
residue 173
type
sequence D
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

34) chain B
residue 175
type
sequence S
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

35) chain B
residue 180
type
sequence P
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

36) chain B
residue 181
type
sequence A
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

37) chain B
residue 183
type
sequence S
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

38) chain B
residue 184
type
sequence L
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

39) chain B
residue 241
type
sequence Y
description BINDING SITE FOR RESIDUE S4M A 502
source : AC2

40) chain A
residue 97-110
type prosite
sequence VLIIGGGDGGVLRE
description PABS_1 Polyamine biosynthesis (PABS) domain signature. VLIIGGGdGgvLrE
source prosite : PS01330

41) chain A
residue 173
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

42) chain B
residue 173
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

43) chain A
residue 49
type BINDING
sequence Q
description
source Swiss-Prot : SWS_FT_FI2

44) chain B
residue 79
type BINDING
sequence Y
description
source Swiss-Prot : SWS_FT_FI2

45) chain B
residue 80
type BINDING
sequence Q
description
source Swiss-Prot : SWS_FT_FI2

46) chain B
residue 104
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI2

47) chain B
residue 124
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI2

48) chain B
residue 155
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI2

49) chain B
residue 173
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI2

50) chain B
residue 241
type BINDING
sequence Y
description
source Swiss-Prot : SWS_FT_FI2

51) chain A
residue 79
type BINDING
sequence Y
description
source Swiss-Prot : SWS_FT_FI2

52) chain A
residue 80
type BINDING
sequence Q
description
source Swiss-Prot : SWS_FT_FI2

53) chain A
residue 104
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI2

54) chain A
residue 124
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI2

55) chain A
residue 155
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI2

56) chain A
residue 173
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI2

57) chain A
residue 241
type BINDING
sequence Y
description
source Swiss-Prot : SWS_FT_FI2

58) chain B
residue 49
type BINDING
sequence Q
description
source Swiss-Prot : SWS_FT_FI2


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