eF-site ID 2o0l-A PDB Code 2o0l Chain A click to enlarge Title Human spermidine synthase Classification TRANSFERASE Compound Spermidine synthase Source Homo sapiens (Human) (SPEE_HUMAN) Sequence A:  IREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFR SKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPR KVLIIGGGDGGVLREVVKHPSVESVVQCEIDEDVIQVSKK FLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSS ESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQS LFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQPL TQQQVAQMQLKYYNSDVHRAAFVLPEFARKALND Description Functional site 1) chain A residue 49 type sequence Q description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 2) chain A residue 70 type sequence Q description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 3) chain A residue 79 type sequence Y description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 4) chain A residue 80 type sequence Q description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 5) chain A residue 101 type sequence G description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 6) chain A residue 103 type sequence G description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 7) chain A residue 104 type sequence D description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 8) chain A residue 123 type sequence C description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 9) chain A residue 124 type sequence E description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 10) chain A residue 125 type sequence I description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 11) chain A residue 126 type sequence D description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 12) chain A residue 129 type sequence V description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 13) chain A residue 154 type sequence G description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 14) chain A residue 155 type sequence D description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 15) chain A residue 156 type sequence G description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 16) chain A residue 173 type sequence D description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 17) chain A residue 241 type sequence Y description BINDING SITE FOR RESIDUE S4M A 501 source : AC1 18) chain A residue 173 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 49 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI2 20) chain A residue 79 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI2 21) chain A residue 80 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI2 22) chain A residue 104 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 23) chain A residue 124 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 24) chain A residue 155 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 25) chain A residue 173 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 26) chain A residue 241 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI2 27) chain A residue 97-110 type prosite sequence VLIIGGGDGGVLRE description PABS_1 Polyamine biosynthesis (PABS) domain signature. VLIIGGGdGgvLrE source prosite : PS01330

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