eF-site ID 2o07-AB PDB Code 2o07 Chain A, B click to enlarge Title Human spermidine synthase Classification TRANSFERASE Compound Spermidine synthase Source Homo sapiens (Human) (SPEE_HUMAN) Sequence A:  IREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFR SKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNPR KVLIIGGGDGGVLREVVKHPSVESVVQCEIDEDVIQVSKK FLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDSS ESYYQLMKTALKEDGVLCCQGECQWLHLDLIKEMRQFCQS LFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQPL TQQQVAQMQLKYYNSDVHRAAFVLPEFARKALND B:  AIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVF RSKTYGNVLVLDGVIQCTERDEFSYQEMIANLPLCSHPNP RKVLIIGGGDGGVLREVVKHPSVESVVQCEIDEDVIQVSK KFLPGMAIGYSSSKLTLHVGDGFEFMKQNQDAFDVIITDS SDPMGPAESLFKESYYQLMKTALKEDGVLCCQGECQWLHL DLIKEMRQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKN PSTNFQEPVQPLTQQQVAQMQLKYYNSDVHRAAFVLPEFA RKALN Description Functional site 1) chain A residue 23 type sequence E description BINDING SITE FOR RESIDUE SPD A 601 source : AC1 2) chain A residue 68 type sequence V description BINDING SITE FOR RESIDUE SPD A 601 source : AC1 3) chain A residue 69 type sequence I description BINDING SITE FOR RESIDUE SPD A 601 source : AC1 4) chain A residue 70 type sequence Q description BINDING SITE FOR RESIDUE SPD A 601 source : AC1 5) chain A residue 79 type sequence Y description BINDING SITE FOR RESIDUE SPD A 601 source : AC1 6) chain A residue 80 type sequence Q description BINDING SITE FOR RESIDUE SPD A 601 source : AC1 7) chain A residue 104 type sequence D description BINDING SITE FOR RESIDUE SPD A 601 source : AC1 8) chain A residue 173 type sequence D description BINDING SITE FOR RESIDUE SPD A 601 source : AC1 9) chain A residue 174 type sequence S description BINDING SITE FOR RESIDUE SPD A 601 source : AC1 10) chain A residue 241 type sequence Y description BINDING SITE FOR RESIDUE SPD A 601 source : AC1 11) chain A residue 242 type sequence P description BINDING SITE FOR RESIDUE SPD A 601 source : AC1 12) chain B residue 28 type sequence W description BINDING SITE FOR RESIDUE SPD B 601 source : AC2 13) chain B residue 68 type sequence V description BINDING SITE FOR RESIDUE SPD B 601 source : AC2 14) chain B residue 70 type sequence Q description BINDING SITE FOR RESIDUE SPD B 601 source : AC2 15) chain B residue 79 type sequence Y description BINDING SITE FOR RESIDUE SPD B 601 source : AC2 16) chain B residue 80 type sequence Q description BINDING SITE FOR RESIDUE SPD B 601 source : AC2 17) chain B residue 104 type sequence D description BINDING SITE FOR RESIDUE SPD B 601 source : AC2 18) chain B residue 173 type sequence D description BINDING SITE FOR RESIDUE SPD B 601 source : AC2 19) chain B residue 174 type sequence S description BINDING SITE FOR RESIDUE SPD B 601 source : AC2 20) chain B residue 176 type sequence D description BINDING SITE FOR RESIDUE SPD B 601 source : AC2 21) chain B residue 241 type sequence Y description BINDING SITE FOR RESIDUE SPD B 601 source : AC2 22) chain A residue 49 type sequence Q description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 23) chain A residue 65 type sequence L description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 24) chain A residue 101 type sequence G description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 25) chain A residue 103 type sequence G description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 26) chain A residue 104 type sequence D description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 27) chain A residue 123 type sequence C description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 28) chain A residue 124 type sequence E description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 29) chain A residue 125 type sequence I description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 30) chain A residue 129 type sequence V description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 31) chain A residue 154 type sequence G description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 32) chain A residue 155 type sequence D description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 33) chain A residue 156 type sequence G description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 34) chain A residue 173 type sequence D description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 35) chain A residue 175 type sequence S description BINDING SITE FOR RESIDUE MTA A 501 source : AC3 36) chain B residue 49 type sequence Q description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 37) chain B residue 65 type sequence L description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 38) chain B residue 101 type sequence G description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 39) chain B residue 103 type sequence G description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 40) chain B residue 104 type sequence D description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 41) chain B residue 123 type sequence C description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 42) chain B residue 124 type sequence E description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 43) chain B residue 125 type sequence I description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 44) chain B residue 126 type sequence D description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 45) chain B residue 129 type sequence V description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 46) chain B residue 154 type sequence G description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 47) chain B residue 155 type sequence D description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 48) chain B residue 156 type sequence G description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 49) chain B residue 173 type sequence D description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 50) chain B residue 180 type sequence P description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 51) chain B residue 181 type sequence A description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 52) chain B residue 183 type sequence S description BINDING SITE FOR RESIDUE MTA B 501 source : AC4 53) chain A residue 97-110 type prosite sequence VLIIGGGDGGVLRE description PABS_1 Polyamine biosynthesis (PABS) domain signature. VLIIGGGdGgvLrE source prosite : PS01330 54) chain A residue 173 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 55) chain B residue 173 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 56) chain A residue 49 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI2 57) chain B residue 79 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI2 58) chain B residue 80 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI2 59) chain B residue 104 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 60) chain B residue 124 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 61) chain B residue 155 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 62) chain B residue 173 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 63) chain B residue 241 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI2 64) chain A residue 79 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI2 65) chain A residue 80 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI2 66) chain A residue 104 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 67) chain A residue 124 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 68) chain A residue 155 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 69) chain A residue 173 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 70) chain A residue 241 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI2 71) chain B residue 49 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI2

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