|
|
eF-site ID
|
2nxd-ABP |
|
PDB Code
|
2nxd |
|
Chain
|
A, B, P |
|
click to enlarge
|
|
|
Title
|
Structure of HIV-1 protease D25N complexed with rt-rh analogue peptide GLY-ALA-ASP-ILE-PHE*TYR-LEU-ASP-GLY-ALA |
|
Classification
|
HYDROLASE/HYDROLASE SUBSTRATE |
|
Compound
|
PROTEASE RETROPEPSIN |
|
Source
|
(2NXD) |
|
|
Sequence
|
A: |
PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG
KWKPKMIGGIGGFIKVRQYDQIPIEICGHKAIGTVLVGPT
PVNIIGRNLLTQIGCTLNF
|
| B: |
PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPG
KWKPKMIGGIGGFIKVRQYDQIPIEICGHKAIGTVLVGPT
PVNIIGRNLLTQIGCTLNF
|
| P: |
ADIFYLDG
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
25 |
| type |
ACT_SITE |
| sequence |
N
|
| description |
For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
B |
| residue |
25 |
| type |
ACT_SITE |
| sequence |
N
|
| description |
For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
A |
| residue |
99 |
| type |
SITE |
| sequence |
F
|
| description |
Cleavage; by viral protease => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
B |
| residue |
99 |
| type |
SITE |
| sequence |
F
|
| description |
Cleavage; by viral protease => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|