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eF-site ID
|
2nvu-I |
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PDB Code
|
2nvu |
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Chain
|
I |
|
click to enlarge
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Title
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Structure of APPBP1-UBA3~NEDD8-NEDD8-MgATP-Ubc12(C111A), a trapped ubiquitin-like protein activation complex |
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Classification
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PROTEIN TURNOVER, LIGASE |
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Compound
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NEDD8-activating enzyme E1 regulatory subunit |
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Source
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Homo sapiens (Human) (NEDD8_HUMAN) |
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Sequence
|
I: |
MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQ
QRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGG
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Description
|
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Functional site
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|
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1)
|
chain |
I |
| residue |
76 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE ATP B 103
|
| source |
: AC3
|
|
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2)
|
chain |
I |
| residue |
8 |
| type |
SITE |
| sequence |
L
|
| description |
Interaction with UBE1C => ECO:0000269|PubMed:14690597
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
|
chain |
I |
| residue |
44 |
| type |
SITE |
| sequence |
I
|
| description |
Interaction with UBE1C => ECO:0000269|PubMed:14690597
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
I |
| residue |
48 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0000250|UniProtKB:P29595
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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5)
|
chain |
I |
| residue |
76 |
| type |
CROSSLNK |
| sequence |
G
|
| description |
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
6)
|
chain |
I |
| residue |
40 |
| type |
MOD_RES |
| sequence |
Q
|
| description |
(Microbial infection) Deamidated glutamine => ECO:0000269|PubMed:20688984, ECO:0000269|PubMed:21903097, ECO:0000269|PubMed:23175788, ECO:0000269|PubMed:23589306, ECO:0000269|PubMed:26632597
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
I |
| residue |
27-52 |
| type |
prosite |
| sequence |
KERVEEKEGIPPQQQRLIYSGKQMND
|
| description |
UBIQUITIN_1 Ubiquitin domain signature. KerVeEkegIPpqqQrLIYsGkqmnD
|
| source |
prosite : PS00299
|
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