eF-site ID 2nvu-B PDB Code 2nvu Chain B click to enlarge Title Structure of APPBP1-UBA3~NEDD8-NEDD8-MgATP-Ubc12(C111A), a trapped ubiquitin-like protein activation complex Classification PROTEIN TURNOVER, LIGASE Compound NEDD8-activating enzyme E1 regulatory subunit Source Homo sapiens (Human) (NEDD8_HUMAN) Sequence B:  KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHP DKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEIT PDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKD LLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPL IAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKV NYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFL ENYLLTDEGLEAVNKDKVALKSYEEEATMENAQKGEIMPN IPQMSAFWYAVRTAVINAASGRQTVDAALAAAQTNAAADW EGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLV IGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFL FRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDT FYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSS IVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNF PMCTIASMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDD PEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVA STNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTY TFEAERKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSAS LQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLK ELGLVDGQELAVADVTTPQTVLFKLHFTS Description Functional site 1) chain B residue 2146 type sequence D description BINDING SITE FOR RESIDUE MG B 101 source : AC1 2) chain B residue 2199 type sequence C description BINDING SITE FOR RESIDUE ZN B 102 source : AC2 3) chain B residue 2202 type sequence C description BINDING SITE FOR RESIDUE ZN B 102 source : AC2 4) chain B residue 2343 type sequence C description BINDING SITE FOR RESIDUE ZN B 102 source : AC2 5) chain B residue 2346 type sequence C description BINDING SITE FOR RESIDUE ZN B 102 source : AC2 6) chain B residue 2056 type sequence A description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 7) chain B residue 2057 type sequence G description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 8) chain B residue 2079 type sequence D description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 9) chain B residue 2080 type sequence M description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 10) chain B residue 2081 type sequence D description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 11) chain B residue 2087 type sequence N description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 12) chain B residue 2090 type sequence R description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 13) chain B residue 2091 type sequence Q description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 14) chain B residue 2103 type sequence K description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 15) chain B residue 2125 type sequence N description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 16) chain B residue 2126 type sequence K description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 17) chain B residue 2127 type sequence I description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 18) chain B residue 2128 type sequence Q description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 19) chain B residue 2144 type sequence G description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 20) chain B residue 2146 type sequence D description BINDING SITE FOR RESIDUE ATP B 103 source : AC3 21) chain B residue 2214-2222 type prosite sequence PMCTIASMP description UBIQUITIN_ACTIVAT_2 Ubiquitin-activating enzyme active site. PMCTIAsMP source prosite : PS00865 22) chain B residue 1108-1125 type prosite sequence PIAVEALSLIYNKDLLPN description SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN source prosite : PS01037

Display surface Download Links