eF-site ID 2nll-B PDB Code 2nll Chain B click to enlarge Title RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA Classification TRANSCRIPTION/DNA Compound DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3') Source Homo sapiens (Human) (2NLL) Sequence B:  DELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSY SCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDS KRLAKRKLIEENREKRRREELEK Description Functional site 1) chain B residue 303 type sequence C description BINDING SITE FOR RESIDUE ZN B 450 source : AC3 2) chain B residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN B 450 source : AC3 3) chain B residue 320 type sequence C description BINDING SITE FOR RESIDUE ZN B 450 source : AC3 4) chain B residue 323 type sequence C description BINDING SITE FOR RESIDUE ZN B 450 source : AC3 5) chain B residue 341 type sequence C description BINDING SITE FOR RESIDUE ZN B 451 source : AC4 6) chain B residue 347 type sequence C description BINDING SITE FOR RESIDUE ZN B 451 source : AC4 7) chain B residue 357 type sequence C description BINDING SITE FOR RESIDUE ZN B 451 source : AC4 8) chain B residue 360 type sequence C description BINDING SITE FOR RESIDUE ZN B 451 source : AC4 9) chain B residue 303-329 type prosite sequence CVVCGDKATGYHYRCITCEGCKGFFRR description NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CvvCg.Dkatgy.HYrcitCegCkgFFrR source prosite : PS00031 10) chain B residue 303-377 type DNA_BIND sequence CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCK YEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLD description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI1 11) chain B residue 303-323 type ZN_FING sequence CVVCGDKATGYHYRCITCEGC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 12) chain B residue 341-365 type ZN_FING sequence CKYEGKCVIDKVTRNQCQECRFKKC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 303 type BINDING sequence C description BINDING => ECO:0000269|PubMed:7746322, ECO:0007744|PDB:2NLL source Swiss-Prot : SWS_FT_FI3 14) chain B residue 306 type BINDING sequence C description BINDING => ECO:0000269|PubMed:7746322, ECO:0007744|PDB:2NLL source Swiss-Prot : SWS_FT_FI3 15) chain B residue 320 type BINDING sequence C description BINDING => ECO:0000269|PubMed:7746322, ECO:0007744|PDB:2NLL source Swiss-Prot : SWS_FT_FI3 16) chain B residue 323 type BINDING sequence C description BINDING => ECO:0000269|PubMed:7746322, ECO:0007744|PDB:2NLL source Swiss-Prot : SWS_FT_FI3 17) chain B residue 341 type BINDING sequence C description BINDING => ECO:0000269|PubMed:7746322, ECO:0007744|PDB:2NLL source Swiss-Prot : SWS_FT_FI3 18) chain B residue 347 type BINDING sequence C description BINDING => ECO:0000269|PubMed:7746322, ECO:0007744|PDB:2NLL source Swiss-Prot : SWS_FT_FI3 19) chain B residue 357 type BINDING sequence C description BINDING => ECO:0000269|PubMed:7746322, ECO:0007744|PDB:2NLL source Swiss-Prot : SWS_FT_FI3 20) chain B residue 360 type BINDING sequence C description BINDING => ECO:0000269|PubMed:7746322, ECO:0007744|PDB:2NLL source Swiss-Prot : SWS_FT_FI3

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