eF-site ID 2ngr-AB PDB Code 2ngr Chain A, B click to enlarge Title TRANSITION STATE COMPLEX FOR GTP HYDROLYSIS BY CDC42: COMPARISONS OF THE HIGH RESOLUTION STRUCTURES FOR CDC42 BOUND TO THE ACTIVE AND CATALYTICALLY COMPROMISED FORMS OF THE CDC42-GAP. Classification HYDROLASE Compound PROTEIN (GTP BINDING PROTEIN (G25K)) Source Homo sapiens (Human) (RHG01_HUMAN) Sequence A:  MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNY AVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLV CFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSAL TQKGLKNVFDEAILAALEPPEPKKSRRCVLL B:  LPNQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALT TEGIFARSANTQVVREVQQKYNMGLPVDFDQYNELHLPAV ILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQV LQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVF GPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFP Description Functional site 1) chain A residue 17 type sequence T description BINDING SITE FOR RESIDUE MG A 199 source : AC1 2) chain A residue 35 type sequence T description BINDING SITE FOR RESIDUE MG A 199 source : AC1 3) chain A residue 13 type sequence A description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 4) chain A residue 14 type sequence V description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 5) chain A residue 15 type sequence G description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 6) chain A residue 16 type sequence K description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 7) chain A residue 17 type sequence T description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 8) chain A residue 18 type sequence C description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 9) chain A residue 28 type sequence F description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 10) chain A residue 32 type sequence Y description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 11) chain A residue 116 type sequence Q description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 12) chain A residue 118 type sequence D description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 13) chain A residue 119 type sequence L description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 14) chain A residue 158 type sequence S description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 15) chain A residue 159 type sequence A description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 16) chain A residue 160 type sequence L description BINDING SITE FOR RESIDUE GDP A 198 source : AC2 17) chain A residue 12 type sequence G description BINDING SITE FOR RESIDUE AF3 A 200 source : AC3 18) chain A residue 13 type sequence A description BINDING SITE FOR RESIDUE AF3 A 200 source : AC3 19) chain A residue 16 type sequence K description BINDING SITE FOR RESIDUE AF3 A 200 source : AC3 20) chain A residue 32 type sequence Y description BINDING SITE FOR RESIDUE AF3 A 200 source : AC3 21) chain A residue 34 type sequence P description BINDING SITE FOR RESIDUE AF3 A 200 source : AC3 22) chain A residue 35 type sequence T description BINDING SITE FOR RESIDUE AF3 A 200 source : AC3 23) chain A residue 60 type sequence G description BINDING SITE FOR RESIDUE AF3 A 200 source : AC3 24) chain A residue 61 type sequence Q description BINDING SITE FOR RESIDUE AF3 A 200 source : AC3 25) chain A residue 35 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059 source Swiss-Prot : SWS_FT_FI9 26) chain A residue 57 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 305 type SITE sequence A description Involved in G-protein binding to GAPs => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 115 type SITE sequence T description Involved in G-protein binding to GAPs => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 32 type MOD_RES sequence Y description (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538, ECO:0000269|PubMed:20622875 source Swiss-Prot : SWS_FT_FI3 30) chain A residue 35 type MOD_RES sequence T description (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103 source Swiss-Prot : SWS_FT_FI4 31) chain A residue 64 type MOD_RES sequence Y description Phosphotyrosine; by SRC => ECO:0000269|PubMed:14506284 source Swiss-Prot : SWS_FT_FI5 32) chain A residue 188 type MOD_RES sequence C description Cysteine methyl ester => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA source Swiss-Prot : SWS_FT_FI6 33) chain A residue 188 type LIPID sequence C description S-geranylgeranyl cysteine => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA source Swiss-Prot : SWS_FT_FI7 34) chain A residue 32 type CARBOHYD sequence Y description (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704 source Swiss-Prot : SWS_FT_FI8

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