eF-site ID 2mp0-AB PDB Code 2mp0 Chain A, B click to enlarge Title Protein Phosphorylation upon a Fleeting Encounter Classification TRANSFERASE Compound Phosphoenolpyruvate-protein phosphotransferase Source (PTGA_ECOLI) Sequence A:  MISGILASPGIAFGKALLLKEDEIVIDRKKISADQVDQEV ERFLSGRAKASAQLETIKTKAGETFGEEKEAIFEGHIMLL EDEELEQEIIALIKDKHMTADAAAHEVIEGQASALEELDD EYLKERAADVRDIGKRLLRNILGLKIIDLSAIQDEVILVA ADLTPSETAQLNLKKVLGFITDAGGRTSHTSIMARSLELP AIVGTGSVTSQVKNDDYLILDAVNNQVYVNPTNEVIDKMR AVQEQVASE B:  TIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNK MVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVEL KGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPV VISNMDEIKELIKLSGSVTVGETPVIRIK Description (1)  Phosphoenolpyruvate-protein phosphotransferase (E.C.2.7.3.9), Glucose-specific phosphotransferase enzyme IIA component (E.C.2.7.1.-) Functional site 1) chain A residue 189 type sequence H description BINDING SITE FOR RESIDUE PO3 B 500 source : AC1 2) chain B residue 371 type sequence F description BINDING SITE FOR RESIDUE PO3 B 500 source : AC1 3) chain B residue 375 type sequence H description BINDING SITE FOR RESIDUE PO3 B 500 source : AC1 4) chain B residue 390 type sequence H description BINDING SITE FOR RESIDUE PO3 B 500 source : AC1 5) chain B residue 396 type sequence V description BINDING SITE FOR RESIDUE PO3 B 500 source : AC1 6) chain B residue 384-396 type prosite sequence GVELFVHFGIDTV description PTS_EIIA_TYPE_1_HIS PTS EIIA domains phosphorylation site signature 1. GveLFVHFGIdTV source prosite : PS00371 7) chain B residue 390 type ACT_SITE sequence H description Tele-phosphohistidine intermediate; for EIIA activity => ECO:0000255|PROSITE-ProRule:PRU00416, ECO:0000269|PubMed:2657735, ECO:0000269|PubMed:6383826, ECO:0000305|PubMed:1961703, ECO:0000305|PubMed:9405042 source Swiss-Prot : SWS_FT_FI1 8) chain B residue 375 type BINDING sequence H description BINDING => ECO:0000269|PubMed:2657735, ECO:0000269|PubMed:8170944, ECO:0000269|PubMed:9405042, ECO:0000305|PubMed:1961703 source Swiss-Prot : SWS_FT_FI2 9) chain B residue 390 type BINDING sequence H description BINDING => ECO:0000269|PubMed:2657735, ECO:0000269|PubMed:8170944, ECO:0000269|PubMed:9405042, ECO:0000305|PubMed:1961703 source Swiss-Prot : SWS_FT_FI2 10) chain B residue 375 type SITE sequence H description Important for phospho-donor activity => ECO:0000269|PubMed:2657735 source Swiss-Prot : SWS_FT_FI3 11) chain B residue 390 type MOD_RES sequence H description Phosphohistidine; by HPr => ECO:0000269|PubMed:2657735 source Swiss-Prot : SWS_FT_FI4 12) chain A residue 184-195 type prosite sequence GGRTSHTSIMAR description PEP_ENZYMES_PHOS_SITE PEP-utilizing enzymes phosphorylation site signature. GGrTsHTSIMAR source prosite : PS00370 13) chain A residue 189 type catalytic sequence H description 920 source MCSA : MCSA1

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