eF-site ID 2mej_2-A
PDB Code 2mej
Model 2
Chain A

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Title Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints
Classification APOPTOSIS
Compound Bcl-2-like protein 1
Source Homo sapiens (Human) (P53_HUMAN)
Sequence A:  MSQSNRELVVDFLSYKLSQKGYSWSQFSMAAVKQALREAG
DEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDG
VNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYL
NDHLEPWIQENGGWDTFVELYGNN
Description


Functional site

1) chain A
residue 133-151
type prosite
sequence LFRDGVNWGRIVAFFSFGG
description BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG
source prosite : PS01080

2) chain A
residue 184-195
type prosite
sequence WIQENGGWDTFV
description BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV
source prosite : PS01258

3) chain A
residue 89-103
type prosite
sequence VKQALREAGDEFELR
description BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR
source prosite : PS01259

4) chain A
residue 7-27
type prosite
sequence SNRELVVDFLSYKLSQKGYSW
description BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW
source prosite : PS01260


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