|
|
eF-site ID
|
2mej_15-B |
|
PDB Code
|
2mej |
|
Model
|
15 |
|
Chain
|
B |
|
click to enlarge
|
|
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Title
|
Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints |
|
Classification
|
APOPTOSIS |
|
Compound
|
Bcl-2-like protein 1 |
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Source
|
Homo sapiens (Human) (P53_HUMAN) |
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|
Sequence
|
B: |
SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFC
QLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRR
CPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHS
VVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTII
TLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLR
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
176 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN B 401
|
| source |
: AC1
|
|
|
2)
|
chain |
B |
| residue |
179 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN B 401
|
| source |
: AC1
|
|
|
3)
|
chain |
B |
| residue |
238 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN B 401
|
| source |
: AC1
|
|
|
4)
|
chain |
B |
| residue |
242 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN B 401
|
| source |
: AC1
|
|
|
5)
|
chain |
B |
| residue |
237-249 |
| type |
prosite |
| sequence |
MCNSSCMGGMNRR
|
| description |
P53 p53 family signature. MCNSSCMGGMNRR
|
| source |
prosite : PS00348
|
|
|
6)
|
chain |
B |
| residue |
176 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
B |
| residue |
179 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
B |
| residue |
238 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
B |
| residue |
242 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
10)
|
chain |
B |
| residue |
120 |
| type |
SITE |
| sequence |
K
|
| description |
Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
11)
|
chain |
B |
| residue |
120 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:23431171
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
12)
|
chain |
B |
| residue |
183 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
13)
|
chain |
B |
| residue |
269 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
14)
|
chain |
B |
| residue |
284 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
|