eF-site ID 2m4z_2-A
PDB Code 2m4z
Model 2
Chain A

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Title Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a).
Classification TOXIN
Compound Mu-theraphotoxin-Hh2a
Source Haplopelma schmidti (Chinese bird spider) (Ornithoctonus huwenum) (TXH4_HAPSC)
Sequence A:  ECLEIFKACNPSNDQCCKSSKLVCSRKTRACKYQI
Description


Functional site

1) chain A
residue 1
type MOD_RES
sequence E
description Pyrrolidone carboxylic acid (Glu); partial => ECO:0000269|PubMed:23826086
source Swiss-Prot : SWS_FT_FI2

2) chain A
residue 35
type MOD_RES
sequence I
description Isoleucine amide => ECO:0000269|PubMed:12228241
source Swiss-Prot : SWS_FT_FI3

3) chain A
residue 6
type SITE
sequence F
description Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A) => ECO:0000305|PubMed:23760503
source Swiss-Prot : SWS_FT_FI1

4) chain A
residue 26
type SITE
sequence R
description Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A) => ECO:0000305|PubMed:23760503
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 27
type SITE
sequence K
description Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A) => ECO:0000305|PubMed:23760503
source Swiss-Prot : SWS_FT_FI1

6) chain A
residue 30
type SITE
sequence A
description Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A) => ECO:0000305|PubMed:23760503
source Swiss-Prot : SWS_FT_FI1

7) chain A
residue 32
type SITE
sequence K
description Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A) => ECO:0000305|PubMed:23760503
source Swiss-Prot : SWS_FT_FI1


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