eF-site ID 2lgk_16-AB
PDB Code 2lgk
Model 16
Chain A, B

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Title NMR Structure of UHRF1 PHD domains in a complex with histone H3 peptide
Classification LIGASE/DNA BINDING PROTEIN
Compound E3 ubiquitin-protein ligase UHRF1
Source Homo sapiens (Human) (2LGK)
Sequence A:  SGPSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECD
MAFHIYCLDPPLSSVPSEDEWYCPECRND
B:  ARTKQTARXSTG
Description


Functional site

1) chain A
residue 315
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 380
source : AC1

2) chain A
residue 318
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 380
source : AC1

3) chain A
residue 326
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 380
source : AC1

4) chain A
residue 329
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 380
source : AC1

5) chain A
residue 331
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 381
source : AC2

6) chain A
residue 334
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 381
source : AC2

7) chain A
residue 354
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 381
source : AC2

8) chain A
residue 357
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 381
source : AC2

9) chain A
residue 346
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 382
source : AC3

10) chain A
residue 349
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 382
source : AC3

11) chain A
residue 373
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 382
source : AC3

12) chain A
residue 376
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 382
source : AC3

13) chain A
residue 315-376
type prosite
sequence CKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFH
IYCLDPPLSSVPSEDEWYCPEC
description ZF_PHD_1 Zinc finger PHD-type signature. CkhCkddvnrlcrvcachlcggrqdpdkq....................LmCde..Cdma.FHiyCldpplssvpsede................................WyCpeC
source prosite : PS01359

14) chain A
residue 329
type SITE
sequence C
description Histone H3K4me0 binding
source Swiss-Prot : SWS_FT_FI2

15) chain A
residue 340
type SITE
sequence P
description Histone H3R2me0 binding
source Swiss-Prot : SWS_FT_FI3

16) chain A
residue 343
type SITE
sequence Q
description Histone H3R2me0 binding
source Swiss-Prot : SWS_FT_FI3

17) chain A
residue 323-379
type ZN_FING
sequence NRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCLDPPL
SSVPSEDEWYCPECRND
description PHD-type => ECO:0000255|PROSITE-ProRule:PRU00146
source Swiss-Prot : SWS_FT_FI1

18) chain A
residue 311
type MOD_RES
sequence S
description Phosphoserine; by PKA => ECO:0000269|PubMed:15178447, ECO:0000269|PubMed:22837395
source Swiss-Prot : SWS_FT_FI4


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