eF-site/Summary 2l31

eF-site ID	2l31_12-A
PDB Code	2l31
Model	12
Chain	A

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Title	Human PARP-1 zinc finger 2
Classification	TRANSFERASE
Compound	Poly [ADP-ribose] polymerase 1
Source	(PARP1_HUMAN)

Sequence	A:	GSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKK MVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLK GFSLLATEDKEALKKQLPGVKSEGKRKGDEVD

Description	(1)	Poly [ADP-ribose] polymerase 1 (E.C.2.4.2.30)

Functional site


1)	chain	A
	residue	125
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN A 215
	source	: AC1

2)	chain	A
	residue	128
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN A 215
	source	: AC1

3)	chain	A
	residue	159
	type
	sequence	H
	description	BINDING SITE FOR RESIDUE ZN A 215
	source	: AC1

4)	chain	A
	residue	162
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN A 215
	source	: AC1

5)	chain	A
	residue	192
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI7

6)	chain	A
	residue	203
	type	CROSSLNK
	sequence	K
	description	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:25772364, ECO:0007744\|PubMed:28112733
	source	Swiss-Prot : SWS_FT_FI8

7)	chain	A
	residue	214
	type	SITE
	sequence	D
	description	Cleavage; by caspase-3 and caspase-7 => ECO:0000269\|PubMed:10497198, ECO:0000269\|PubMed:22464733, ECO:0000269\|PubMed:7596430
	source	Swiss-Prot : SWS_FT_FI3

8)	chain	A
	residue	177
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0007744\|PubMed:23186163
	source	Swiss-Prot : SWS_FT_FI5

9)	chain	A
	residue	185
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0007744\|PubMed:23186163
	source	Swiss-Prot : SWS_FT_FI5

10)	chain	A
	residue	179
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0007744\|PubMed:17525332, ECO:0007744\|PubMed:23186163
	source	Swiss-Prot : SWS_FT_FI6

11)	chain	A
	residue	125-162
	type	prosite
	sequence	CKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGC
	description	ZF_PARP_1 Zinc finger poly(ADP-ribose) polymerase (PARP)-type signature. CKgCmekIeKgqvRlskkmvdpekpqlgmidrWYHpgC
	source	prosite : PS00347

12)	chain	A
	residue	125
	type	BINDING
	sequence	C
	description	BINDING => ECO:0000255\|PROSITE-ProRule:PRU00264, ECO:0000269\|PubMed:21233213, ECO:0000269\|PubMed:22683995, ECO:0007744\|PDB:3ODC, ECO:0007744\|PDB:3ODE, ECO:0007744\|PDB:4AV1
	source	Swiss-Prot : SWS_FT_FI2

13)	chain	A
	residue	128
	type	BINDING
	sequence	C
	description	BINDING => ECO:0000255\|PROSITE-ProRule:PRU00264, ECO:0000269\|PubMed:21233213, ECO:0000269\|PubMed:22683995, ECO:0007744\|PDB:3ODC, ECO:0007744\|PDB:3ODE, ECO:0007744\|PDB:4AV1
	source	Swiss-Prot : SWS_FT_FI2

14)	chain	A
	residue	159
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000255\|PROSITE-ProRule:PRU00264, ECO:0000269\|PubMed:21233213, ECO:0000269\|PubMed:22683995, ECO:0007744\|PDB:3ODC, ECO:0007744\|PDB:3ODE, ECO:0007744\|PDB:4AV1
	source	Swiss-Prot : SWS_FT_FI2

15)	chain	A
	residue	162
	type	BINDING
	sequence	C
	description	BINDING => ECO:0000255\|PROSITE-ProRule:PRU00264, ECO:0000269\|PubMed:21233213, ECO:0000269\|PubMed:22683995, ECO:0007744\|PDB:3ODC, ECO:0007744\|PDB:3ODE, ECO:0007744\|PDB:4AV1
	source	Swiss-Prot : SWS_FT_FI2

16)	chain	A
	residue	105
	type	MOD_RES
	sequence	K
	description	N6-acetyllysine => ECO:0007744\|PubMed:19608861
	source	Swiss-Prot : SWS_FT_FI4

17)	chain	A
	residue	131
	type	MOD_RES
	sequence	K
	description	N6-acetyllysine => ECO:0007744\|PubMed:19608861
	source	Swiss-Prot : SWS_FT_FI4

18)	chain	A
	residue	113-203
	type	ZN_FING
	sequence	FAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLG MIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDK EALKKQLPGVK
	description	PARP-type 2 => ECO:0000255\|PROSITE-ProRule:PRU00264
	source	Swiss-Prot : SWS_FT_FI1