eF-site ID 2l0j_6-C
PDB Code 2l0j
Model 6
Chain C

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Title Solid State NMR structure of the M2 proton channel from Influenza A Virus in hydrated lipid bilayer
Classification TRANSPORT PROTEIN
Compound Matrix protein 2
Source Influenza A virus (strain A/Udorn/307/1972 H3N2) (M2_I72A2)
Sequence C:  SSDPLVVAASIIGILHLILWILDRLFFKSIYRFFEHGLKR
G
Description (1)  Matrix protein 2


Functional site

1) chain C
residue 23-43
type TRANSMEM
sequence SDPLVVAASIIGILHLILWIL
description Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI1

2) chain C
residue 41
type SITE
sequence W
description Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI3

3) chain C
residue 50
type LIPID
sequence S
description S-palmitoyl cysteine; by host => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI4

4) chain C
residue 37
type SITE
sequence H
description Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI2


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