eF-site ID 2l0j_5-ABCD
PDB Code 2l0j
Model 5
Chain A, B, C, D

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Title Solid State NMR structure of the M2 proton channel from Influenza A Virus in hydrated lipid bilayer
Classification TRANSPORT PROTEIN
Compound Matrix protein 2
Source Influenza A virus (strain A/Udorn/307/1972 H3N2) (M2_I72A2)
Sequence A:  SSDPLVVAASIIGILHLILWILDRLFFKSIYRFFEHGLKR
G
B:  SSDPLVVAASIIGILHLILWILDRLFFKSIYRFFEHGLKR
G
C:  SSDPLVVAASIIGILHLILWILDRLFFKSIYRFFEHGLKR
G
D:  SSDPLVVAASIIGILHLILWILDRLFFKSIYRFFEHGLKR
G
Description (1)  Matrix protein 2


Functional site

1) chain A
residue 23-43
type TRANSMEM
sequence SDPLVVAASIIGILHLILWIL
description Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI1

2) chain B
residue 23-43
type TRANSMEM
sequence SDPLVVAASIIGILHLILWIL
description Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI1

3) chain C
residue 23-43
type TRANSMEM
sequence SDPLVVAASIIGILHLILWIL
description Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI1

4) chain D
residue 23-43
type TRANSMEM
sequence SDPLVVAASIIGILHLILWIL
description Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 41
type SITE
sequence W
description Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI3

6) chain B
residue 41
type SITE
sequence W
description Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI3

7) chain C
residue 41
type SITE
sequence W
description Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI3

8) chain D
residue 41
type SITE
sequence W
description Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI3

9) chain A
residue 50
type LIPID
sequence S
description S-palmitoyl cysteine; by host => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI4

10) chain B
residue 50
type LIPID
sequence S
description S-palmitoyl cysteine; by host => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI4

11) chain C
residue 50
type LIPID
sequence S
description S-palmitoyl cysteine; by host => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI4

12) chain D
residue 50
type LIPID
sequence S
description S-palmitoyl cysteine; by host => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI4

13) chain A
residue 37
type SITE
sequence H
description Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI2

14) chain B
residue 37
type SITE
sequence H
description Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI2

15) chain C
residue 37
type SITE
sequence H
description Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI2

16) chain D
residue 37
type SITE
sequence H
description Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069
source Swiss-Prot : SWS_FT_FI2


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